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Information × Registration Number 0210U001674, 0107U005542 , R & D reports Title Effect of soybean foods on experimental tumor growth and ancillary biochemical and hematological indices popup.stage_title Head Zaletok Sophia Petrivna, Registration Date 17-03-2010 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 During experimental trial of a series of soybean foods been produced in the Institute of Engineering Thermophysics of NAS of Ukraine, it was demonstrated that If part of soybean protein in total forage protein was magnified in the interval of 0 - 40%, this led to increasing growth retardation of rat Walker W-256 carcinosarcoma. If part of soybean protein in total forage protein was constant (25%), the maximum growth retardation of rat Walker W-256 carcinosarcoma and Guerin's carcinoma and also mouse Ca755 carcinoma was observed under isoflavones-free isolate of soybean protein. Presence of the isoflavones (0,1% - 4,0% weight) in the soybean protein isolate diminished or completely abolished growth retardation. This effect was practically identical as to three experimental tumor strains, in spite of their estrogene-dependence. Highly probable is a hypothesis that soy includes one or more substances, most probable not being proteins, having a property to bind both animal estrogens and certain other boosters of tumor growth as well as soybean phytoestrogens. Resulting anti-tumor effect of a concrete soybean product appears a resultant of soybean phytoestrogens effect and effect of a soybean blocker of the growth boosters. Measurements of MDA content in liver tissue of the tumor-bearing animals have demonstrated detoxicant effect of both soybean protein isolate itstlf and soybean isoflavones. Healthy rats fed with forage containing soybean protein isolate have demonstrated essential leucocytosis in peripheral blood. This may be interpreted as a reaction on a foreign protein. If isoflavones content in the soybean protein isolate was increased up to 2% of weight, this effect was removed. It was not observed any statistically significant effect of soybean protein isolate on AlAT and AsAT enzymes activity in the animals' blood serum. Also statistically significant effect of soybean protein isolate on erythrocytes content in pripheral blood was absent both in healthy and tumor-bearing animals. Product Description popup.authors Гоголь Сергій Володимирович Залєток Софія Петрівна Кленов Олег Олександрович Малицька Інна Володимирівна Нестеренко Раїса Кузьмівна Орловський Олексій Аркадієвич Самойленко Олена Анатоліївна popup.nrat_date 2020-04-02 Close