Registration Number
0210U003459,
0107U000529
, R & D reports
Title
Molecular-cell mechanisms of nervous system pathology development of complex methods of early diagnostic
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Head
Chorna Valentina Ivanivna,
Registration Date
04-02-2010
Organization
Dniepropetrovsk national university
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The dynamics of neurospecific proteins and cysteine lysosomal proteases were researched in functionally and morphologically different brain structures, blood serum under neurogenic stress, hyperalgesia and oncodeseases of brain. The indices of animals' physiological state were established under correction of postoperative somatogenic pain by metallotioneines (MT-II) and carcinogenesis. The scheme of methodologic ways of quantitive characteristics of neuronal and astroglial cells was developed using neurochemical and biochemical indices (neuronspecific (NCAM) and astroglial (GFAP and S100b)) and lysosomal proteases. The conception of intracellular interactions in central nervous system was developed on the base of researching molecular mechanisms of neurospecific proteins (GFAP, NCAM, S100b) distribution and enzymes of protein exchange (cysteine lysosomal cathepsins B, L, H) and their endogeneous inhibitors at the early stages of nervous system pathology development.
Product Description
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Лянна Ольга Леонідівна
Тарковська Альона Володимирівна
Татаровський Олександр Петрович
Ушакова Галина Олександрівна
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2020-04-02
