Registration Number
0210U003713,
0105U002871
, R & D reports
Title
Etiopatogenetic factors of the risk of development of cacer of of the genesial system organs for women and their influence on motion and lokal recidive.
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Head
Khartashov Sergey,
Registration Date
25-02-2010
Organization
The Kharkiv Post-graduate Medical Academy
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Investigated the results of treatment and flow ofillness brest cancer on the basis of quantitative and grade estimation of factors, which determine appearance, progress and flow of illness. Determined the new way of decision of important scientific medical problem of the day is certain is overcoming of the resistans of tumour cells to radio-therapy and search of new approaches and methods which provide a selective management radiosensetivity on the basis of induction of ceramide way of apoptosis. New information which touch the mechanisms of synthesis and accumulation of ceramide in a tumour is got, the mechanisms of induction of ceramide way of apoptosis are exposed under act of radiomodifiers of taxoter and etoposide. The nosotropic grounded method of the radiomodified radial therapy is developed with taxoter and etoposide, which is providing in substantial reduction of tumour by an apoptosis. The method of accompanying therapy is offered by preparations of plant and animal origin for the correction of homoeostasis of oncologic patients in the process of radial therapy with the radiomodifier of taxoter . At hyperplastic processes and Ce (cancer of endometrium) a change adjusting of expression of genes of hMLH1 and APS is set by their metylation which matters for a clinical flow these processes. The value of level of endogenous Ifn-b (interferon) and TNF (factor of necrosis of tumours) is grounded in blood, to proliferative activity of epithelium of neck of uterus and AI (apoptose index) for the origin of integration of HPV 16 to the type in the genome of cell and the role of factor of integration in progression of precancer is rotined in invasive cencer coli uteri. The clinical value of change the concentration of cytocines of interferon and TNF is certain in the whey of blood of patients on cencer coli uteri, associated from HPV 16 and 18 types. The prognostic value of level of cytocine is studied in tumour fabric, apoptosis indexes and expression of gene р16. The method of improvement of diagnostics and results of treatment of ovarium cancer is certain. After materials of NIR: " Executed and protected a 1 dissertation on the receipt of degree of doctor of medical sciences, 5 dissertations on the receipt of candidate of medical sciences; " The 92 scientific are printed works; " Fact sheets and scientific positions are approved on congresses, conventions and conferences and protected the 9-ма patents of Ukraine on an invention.
Product Description
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Єгоров О.О.
Акуліна О.О.
Білодід О.О.
Водолазька Л.П.
Неффа М.Ю.
ПушкарС.М.
Скрицька Т.В.
Удербаєва Г.Ж.
Шалькова Г.Ю.
Шалькова М.Ю.
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2020-04-02
