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Information × Registration Number 0210U006822, 0107U010171 , R & D reports Title To work out and to carry out the evidence complex, aimed at reducing the frequency of gestational and perinatal complications, caused by iodine deficiency popup.stage_title Head Dyemina Tatyana Nikolajevna, Registration Date 17-12-2010 Organization Donetsk National Medical University after named Gorky popup.description2 Developed a scientifically sound set of inspection and treatment of pregnant women with iodine deficiency, taking into account the degree of iodine deficiency (isolated iodine deficiency and complicated with relative hypothyroxinemia), and thyroid hormone status and functioning of the pituitary-thyroid system in the dynamics of gestation, the functions of the placenta, fetus and newborn. It was established that 56,32% of pregnant women in the Donetsk region have iodine deficiency, and 36,36% of such patients have a relative form hypothyroxinemia. Proved that the III trimester in women with iodine deficiency was observed a progressive decline in free thyroxine on 7-10,00% of the original, which led to the formation of subclinical and symptomatic stages of hypothyroidism. By the end of gestation period in 30,00% of women were diagnosed with diffuse goiter I degree. A positive linear relationship of progesterone level on the concentration of free thyroxine and a negative correlation between the level of androgen and thyroxine, which showed a high degree of influence of thyroid hormones in the mother. Proved that the level of free thyroxine in patients with major gestational and perinatal complications was significantly lower than women with no such pathology. Implementation of the developed complex diagnostic and therapeutic and prophylactic measures in pregnant women with isolated iodine deficiency and complicated with relative hypothyroxinemia possible to reduce the incidence of: subclinical hypothyroidism stage - 13 times; symptomatic stage of hypothyroidism - in 4,4 times; premature birth - in 6,7 and 4,1 times, preeclampsia of average and severe degree - in 3,5 and 5,3 times, fetal distress - in 2,2 and 5 times; central nervous system perinatal lesions in newborns - 2 and 4,3 times. Product Description popup.authors Єрмаченко Анна Олександрівна Белоусов Олег Генадійович Дьоміна Тетяна Миколаївна Мєжова Ольга Костянтинівна Пилипенко Ольга Миколаївна Фірсова Наталія Олександрівна Шпатусько Микола Іванович popup.nrat_date 2020-04-02 Close