Registration Number
0210U007131,
0107U004462
, R & D reports
Title
Medical-informative research of experimental pathology of internals at different functional terms and its correction
popup.stage_title
Head
Gudyma Arsen Arsenovych,
Registration Date
20-09-2010
Organization
Ternopol State Medical University by I.Ya.Horbachevsky
popup.description2
Report about scientific work: 99 pages, 51 figures, 10 tables, 99 sources. A research object is a compartment nonlinear pharmacodynamic model, generalized internals, metabolism in myocardium of rats of different sex, cholinergic processes in rat's heart of different sex, heavy mechanical trauma connected with the mechanical and thermal damage 10 % surfaces of skin. Purpose of work is study of influencing of hormone replacement therapy at does on adjusting of cardiac rhythm by the nervous system at development of necrotizing process in myocardium; study of influencing of the deficit of sexual hormones, caused by castration, on the state of the NO system at the animals of different sex; determination of nosotropic features of motion of polytrauma in combination with the mechanical and thermal damage of skin and its correction by xenodermoplastic; finding out of efficiency of protracted oxygination in the conditions of correction of animals with sharp tetrachlormetan hepatitis; study of comparative efficiency of peritoneal dialysis and different variants of continuous oxygen therape of experimental pancreanecrosis in rats; development of model of software environment of evaluation of knowledges in medical education; research of forming of arrays of wares at the division of glass streams on the lines of overflow of medications; explanation on the basis of rheoretico-probabilistic approach of mathematical model, methods of treatment and imitation design of the synchronously registered signals for the necessities of its functional diagnostics on the base of computer; analysis of existent software which is used in pharmacodynamic researches, and development of the Web-integrated software environment which will realize the basic mathematical models of introduction of medicinal preparation. Research methods are functional, electro-physiology, biochemical, morphological, mathematical. It is set that the gonadectomy of females has by investigation of strengthening of the adrenergic influencing from the side of nervous system on operation of heart. Replacement monotherapy by gexestrol does not cause renewal of initial vegetative balance, keeping high activity of likable link and, as counterbalance, of parasympathetic part of nervous system, that testifies to tension of regulators mechanisms. The combined replacement therapy by gexestrol and progesteron is instrumental in renewal of balance of both links of adjusting of heart at females after deleted gonads. Development of necrotizing process in myocardium of at females after deleted gonads is accompanied by the substantial diminishing of adrenergic control of operation of heart and activating of parasympathetic part of nervous system. The only combined replacement therapy is instrumental in the maximal approaching of absolute values and dynamics of indexes of the necrotizing damage of myocardium to those which are registered at animals with sex glands. A gonadectomy results in diminishing of maintenance of NO both in a blood and in myocardium of rats of both sexes, however much more substantial changes arise up at females, that testifies to modulating influences of sexual hormones on the state of the NO system. At animals with with sex glands effects of L-arginin - straight depend on sex and hormonal status of organism, and stronger expressed at males. At rats after deleted gonads effects from application of L- arginin stronger are expressed at females, that testifies to the greater sensitiveness of the NO system to the changes of level exactly womanish sexual hormones, than masculine. In the conditions of the designed heavy trauma comparatively with a control group the gradual decline of bilesentisation, bile-elimination indexes of liver are marked, and also growth of activity of markers enzymes of cytolysis, lypoperoxydation products and endogenous intoxication, sign of exhaustion of antioxydation defence from the first to seventh days of supervision. Additional mechanical damage 10 % to the surface of skin is accompanied by the substantial worsening of the explored indexes and growth of death rate of animals, which on seventh days achieves 60,0 %. In the conditions of application of xenodermoplastic the improvement of most indexes of bilesentisation, bile-elimination and glycogensentisation functions of liver is marked, activity goes down in the whey of blood of markers enzymes of cytolysis, maintenance of endotoxins and lypoperoxydation products on a background the increase of indexes of antioxydation defence. The death rate of animals is not observed thus. The similar positive changes arise up and on a background the additional causing of burn of a ІІІ А-B degree changes of the staggered animals on a background xenodermoplastic are the display of its system influence on an organism. In the conditions of correction of sharp toxic defeat of liver by a tetrachloromethane, enteral oxygenation is accompanied by the expressed positive effect: normalization of markers enzymes of cytolysis and concentration of diencojugates comes, substantially maintenance goes down in the whey of blood of TBA-active products, the indexes of antioxydation defence get better, for statistically certain maintenance goes down in the whey of blood and basic classes of immunoproteins. The use of peritoneal dialysis and continuous small entestine oxygenation in complex therapy of pancreanecrosis causes the improvement of most markers indexes of biochemical blood test. On the whole, medical efficiency of peritoneal dialysis was higher as compared to efficiency of continuous small entestine oxygenation. However much the last in a greater measure normalized processes PAUL and the activity of the antioxydative system of blood related to them. The developed algorithmic providing and his programmatic realization decides the task of forming of base of tasks for the leadthrough of the complex semester testing, formalizes and automatizes a process evaluation and treatment of testing results by AbbyFormReader software, that provides verification of answers real-time, independence of evaluation of results of studies guarantees and eliminates subjective influence on the results of evaluation, is instrumental in upgrading processes of teaching and mastering of disciplines, promotes efficiency of studies by motivation of independent and systematic work. On basis research of forming of arrays of wares at the division of glass streams on the lines of overflow of medications the device is offered for the division of stream of wares provides effective work due to the greater rate of movement of wares in the process of transporting and can find the use on production. The statistical methods of compatible analysis of synchronously registered cardiosignals on the base of their model as the vector of cyclic rhythmically tied-up casual processes are developed and set advantages of such method of analysis in comparison with the methods of treatment of cardiosignals on the basis of their model as the vector of periodically tied-up casual processes. A programmatic complex that gives to conduct possibility compatible statistical treatment of synchronously registered cardiosignals and their design on the basis of model of vector of cyclic rhythmically tied-up casual processes is developed. Estimation of exactness of imitation design is conducted, offered to use, as diagnostic signs, coefficients of curriculum of the got statistical estimations of cardiosignals in the base of trigonometric functions. The analysis of software which is used for the leadthrough of pharmacodynamic researches is carried out. The Web-integrated software environment, the library of Java-classes, which allows to design the basic methods of introduction of medicinal preparations, enters in composition of which, is offered.
Product Description
popup.authors
Андрущак І.Є.
Гудима Арсен Арсенович
Дорохіна Анна Миколаївна
Зятковська Олена Ярославівна
Кравець Наталія Орестівна
Ляхович Роман Мар'янович
Пелих Володимир Євгенович
Сверстюк Андрій Степанович
Секела Тетяна Ярославівна
Семенець Андрій Володимирович
Сушко Юрій Іванович
Хара Марія Романівана
popup.nrat_date
2020-04-02
