Registration Number
0211U000142,
0108U001048
, R & D reports
Title
To develop new technologies of nursing of newborns from mothers with TORCH-infections on the basis of definition of their features immunology adaptations and systems of a hemostasis
popup.stage_title
Head
Znamenskaya T.K.,
Registration Date
19-01-2011
Organization
State enterprise "Institute of Pediatrics, Obstetrics and Gynaecology Academy of Medical Sciences of Ukraine"
popup.description2
Pathomorphology researches of placenta showed the expressed violations at combination of a few infections. Expressive intensity and diffusion of the mesenchymal factor Vimintin in stroma and endothelium of placenta vessels are set. High expression and diffusion of proinflammatory cytokine (interleukin-6)is marked, that can be the early marker of prenatal infection. The increase of activity of complement in the umbilical cord blood of children from the mothers infected toxoplasm is exposed. Changes of thrombocyte link (increase of thrombocyte aggregation activity and decrease of their number) at children from mothers with mix-infection and with herpes viral shows on the higher risk of thrombosis. The exposed hypercoagulation with the increase of concentration of fibrin degradation products at children from mothers with a mix-infection and cytomegalovirus specifies on the increase of coagulative potential and risk of development of DIC-syndrome. Increase of concentration of nitrogen oxide in urine of new-born it is possible to examine as compensating. Concentration IL-6 and IL-8 at new-born from the infected mothers are increased, that they can be used as marker of infectious process severity. The method of treatment of new-born with the prenatal infection with the use of domestic immunoglobulins is offered, his efficiency is proved.
Product Description
popup.authors
Є Зброжек
А.Писарєв
В.Заєць
В.Срібна
В.Тищенко
В.Чернишов
Г.Швець
К. Саюн
К.Костюкова
Л. Мацевич
Л.Шевченко
О.Єщенко
О.Жданович
О.Калиновський
О.Пояркова
С.Стрижак
Т.Задорожна
Т.Коломійченко
Т.Куріліна
Т.Радиш
popup.nrat_date
2020-04-02
