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Information × Registration Number 0211U000173, 0108U000465 , R & D reports Title To investigate the basic cellular-molecular mechanisms of infringements of antineoplastic immunity in patients with B-cellular chronic lymphocytic leukaemia. popup.stage_title Head Isakova L. M., Registration Date 24-01-2011 Organization State Institution "Institute of Haematology and Transfusiology AMS Ukraine" popup.description2 Object of research patients with B-CLL. Methods: general clinical, hematological, cytochemical, flow cytometrie, immunologic. Results of research: in patients with B-CLL it is revealed disbalance the basis cellular effectors of antineoplastic immunity: CD3+CD4 +-, CD3+CD8 +-, CD16+CD56 +-, CD3+CD16+CD56 +-limfocytes. The oppression mechanism of reactions of antineoplastic immunity is expression insufficient costymulatory molecules of family B7 (В7.1/CD80, В7.2/CD86) at tumoral cells and ligand CD28 at CD3 Т-lymphocytes. Expression of functionally active ligand CD95 and hyperexpression an antiapoptosis protein bcl-2 at tumoral CD19 +-limphocytes are the cellular-molecular mechanism of ecaping from immune supervision and the reason immonoresistance of tumoral clone. Display of autoagrression into endocellular structures is increase of autoantibody to double warp dsDNA. Changes of humoral immunity and occurrence of auto antibodies to antigenes of red cells and platelets testifies to functional failure in B-system of immunity.Medical-social effect. Medicine. Product Description popup.authors Ісакова Л. М. Гордієнко А.І. Загоруйко Н.Л. Павлюк Р.П. Перехрестенко Т.П. Тимошенко У.В. Третяк Н.М. Шороп Є.В. popup.nrat_date 2020-04-02 Close