Registration Number
0211U002269,
0108U000027
, R & D reports
Title
To work out methods of prognosing and prevention of repeated coronary events in patients after acute coronary syndromes.
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Head
Mykola Kopytsya,
Registration Date
28-01-2011
Organization
State organization "Therapy Institute named after L.T. Malaya of Ukrainian Academy of Medical Sciences"
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With the aim of design methods of prediction and prevention of recurrent coronary events 200 patients with acute coronary syndrome (ACS) were surveyed - 137 male and 63 female. Methods of survey and equipment - electrocardiographiya, ehocardiographiya, detection level lipids in blood, glucose in blood, troponin I, CK-MB biochemical blood assay for differential diagnostic of ACS. BNP, CRP, NT pro-BNP, leptin, interleukin-6, interleukin-10 levels were detected by immunoenzyme assay. Most predictive value for recurrent heart attack in 6 months after ACS was determined score-factor reduction of IL-10 level, which is consisted by level difference of IL-10 on the 7th and the 1st days of ACS. IL-10 level reduction on the 7th day of ACS less than 2,62 pg/ml in comparison with the 1st day level of ACS may be positive prediction marker in recurrent heart attack development. Detection of sensitive and specificity NT-pro BNP in prognosis recurrent lethal result. Threshold value NT pro-BNP > 1270,3 pg/ml. Construction of math model with considering of markers sum - NT pro-BNP level, patients age, hemoglobin level, heart rate in admission enables complications (lethal result, stroke, recurrent MI, unstable angina and urgent revascularisation) in patients of ACS. Troponin I level detection probably might increase accuracy of diagnostic of ACS.
Product Description
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Біла Н.В.
Ващенко В.Г.
Грібенко Ю.Ю.
Дегтярьова О.В.
Крахмалова О.О.
Литвин О.І.
Набережнов М.Ю.
Пєтєньова Л.Л.
Петюніна О.В.
Титаренко Н.В.
Юхновcький О.Ю.
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2020-04-02
