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Information × Registration Number 0211U004149, 0101U012672 , R & D reports Title To develope the methods of synthesis of the new physiological active substances, derivatives of condensed, noncondensed and macroheterocyclic azolidones, to study their physical and chemical properties and biological action, to research the different kinds of western region plants to get the potential drugs, to develop technology of medicine forms of new composition and to work out the modern methodological approaches of their analysis popup.stage_title Head Zimenkovsky Borys Semenovych, Registration Date 21-02-2011 Organization Danylo Halytsky Lviv National Medical University popup.description2 The objects of investigation are newly synthesized and extracted from plant sources new biological active substances and also substances which can be found in biological objects and be applied in national economy and in medicine. Using a purposeful synthesis about 500 not-mentioned in scientific chemical literature compounds were obtained: heterocyclic compounds derivatives, 5-aroylmethyl-4-thyazolidones, 5-aryl-6,6-dihydro-2H-pyrazolo[1,5-c]benzo[e]-1,3-oxazyno-2-spyro-4'-thyazolidine-2'-ones, bicyclical non-condensed thyazolidone, 2,4-thyazolidinedione-2-thiosemicarbazones, 4,6-dithio-1,2,9-triaza-spiro[4.4]nonen-2 and 4-azolidone-3-propionic acids derivatives. The biological activity screening of some compounds was performed. A great number of these compounds were found to posses anticancer, antimicrobial, anti-inflammatory and anti-tuberculosis activities. The pharmacognostic and photochemical researches of a series of Western region plants were carried out and a number of biological active compounds were extracted and identified. The optimal preparation conditions were developed and pharmacological activity was studied for phyto-substances and phyto-complexes of the researched plant sources which were determined to be promising for phyto-based drugs obtaining. The optimal compositions and preparation technologies were worked out for the new drugs of local action - liniments, pastes, films, gels, elixirs, sprays for using in dentistry and dermatology and also emulsion anti-mastitis drug for using in veterinary medicine. The quantitative analysis methodologies for biological active compounds in substances and drugs, extraction and analysis methods of toxic substances in biological objects and environment were developed by the means of physical-chemical research methods. Product Description popup.authors Алексевич Ярослав Ілліч Антонюк Володимир Олександрович Білоус Світлана Богданівна Бензель Леонід Васильович Ващенко Катерина Фролівна Владзiмiрська Олена Василівна Воробець Наталя Миколаївна Галькевич Iрина Йосипівна Гасс Роман Станіславович Голос Ірина Ярославівна Горiшний Володимир Ярославович Грабоус Олександра Миронівна Дармограй Роман Євдокимович Казмiрчук Генадій Володимирович Калинюк Тимофій Григорович Комариця Йосип Дмитрович Лесик Роман Богданович Музиченко Володимир Панасович Огурцов Володимир Вікторович Піняжко Олег Романович popup.nrat_date 2020-04-02 Close