Registration Number
0211U004149,
0101U012672
, R & D reports
Title
To develope the methods of synthesis of the new physiological active substances, derivatives of condensed, noncondensed and macroheterocyclic azolidones, to study their physical and chemical properties and biological action, to research the different kinds of western region plants to get the potential drugs, to develop technology of medicine forms of new composition and to work out the modern methodological approaches of their analysis
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Head
Zimenkovsky Borys Semenovych,
Registration Date
21-02-2011
Organization
Danylo Halytsky Lviv National Medical University
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The objects of investigation are newly synthesized and extracted from plant sources new biological active substances and also substances which can be found in biological objects and be applied in national economy and in medicine. Using a purposeful synthesis about 500 not-mentioned in scientific chemical literature compounds were obtained: heterocyclic compounds derivatives, 5-aroylmethyl-4-thyazolidones, 5-aryl-6,6-dihydro-2H-pyrazolo[1,5-c]benzo[e]-1,3-oxazyno-2-spyro-4'-thyazolidine-2'-ones, bicyclical non-condensed thyazolidone, 2,4-thyazolidinedione-2-thiosemicarbazones, 4,6-dithio-1,2,9-triaza-spiro[4.4]nonen-2 and 4-azolidone-3-propionic acids derivatives. The biological activity screening of some compounds was performed. A great number of these compounds were found to posses anticancer, antimicrobial, anti-inflammatory and anti-tuberculosis activities. The pharmacognostic and photochemical researches of a series of Western region plants were carried out and a number of biological active compounds were extracted and identified. The optimal preparation conditions were developed and pharmacological activity was studied for phyto-substances and phyto-complexes of the researched plant sources which were determined to be promising for phyto-based drugs obtaining. The optimal compositions and preparation technologies were worked out for the new drugs of local action - liniments, pastes, films, gels, elixirs, sprays for using in dentistry and dermatology and also emulsion anti-mastitis drug for using in veterinary medicine. The quantitative analysis methodologies for biological active compounds in substances and drugs, extraction and analysis methods of toxic substances in biological objects and environment were developed by the means of physical-chemical research methods.
Product Description
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Алексевич Ярослав Ілліч
Антонюк Володимир Олександрович
Білоус Світлана Богданівна
Бензель Леонід Васильович
Ващенко Катерина Фролівна
Владзiмiрська Олена Василівна
Воробець Наталя Миколаївна
Галькевич Iрина Йосипівна
Гасс Роман Станіславович
Голос Ірина Ярославівна
Горiшний Володимир Ярославович
Грабоус Олександра Миронівна
Дармограй Роман Євдокимович
Казмiрчук Генадій Володимирович
Калинюк Тимофій Григорович
Комариця Йосип Дмитрович
Лесик Роман Богданович
Музиченко Володимир Панасович
Огурцов Володимир Вікторович
Піняжко Олег Романович
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2020-04-02