Registration Number
0211U005644,
0111U008000
, R & D reports
Title
Protein-lipid interactions as determinant of protein amyloidogenic properties
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Head
Trusova Valeriya Mikhailivna, Доктор фізико-математичних наук
Registration Date
19-12-2011
Organization
Kharkov National University named after V.N. Karazin
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Modelling of electrostatic controlled adsorption of protein on the membrane surface for non-associating and self-associating ligands was performed. It was found that adsorptive behaviour of monomers is characterized by the highest sensitivity to the changes of the protein aggregation state. The interaction between cytochrome c and lipid bilayers composed of phosphatidylcholine and cardiolipin was studied by the resonance energy transfer method. Based on the Monte Carlo analysis of multidimentional data arrays it was suggested that cardiolipin content and ionic strength modulate the ratio between lateral redistribution of lipids, cardiolipin transition to extended conformation and the formation of hexagonal phase.
Product Description
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Вус К.О.
Касторна А.П.
Куценко О.К.
Трусова В.М.
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2020-04-02
