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Information × Registration Number 0211U006244, 0107U009690 , R & D reports Title Mechanisms of enhancing sensitivity of leukemic cells to chemotherapeutic drugs using natural modifiers of apoptosis popup.stage_title Head Philchenkov Olexy Olexiyovych, Registration Date 02-03-2011 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Jurkat/А4 cells obtained upon exposure of Jurkat T-cell human leukemia cells to anti-Fas monoclonal antibody and possessing multiple drug resistance phenotype have been shown to be resistance to X-ray radiation and apoptosis induction by natural polyphenols quercetin and resveratrol. In Jurkat/А4 cells, the content of proapoptotic proteins Bad and BNip-1 was reduced, while the content of antiapoptotic proteins CAS and XIAP was elevated as compared with that in the initial Jurkat cell line. The irradiation of Jurkat/А4 cells followed by quercetin exposure resulted in the enhancement of the apoptotic effect of ionizing radiation. In cells of patients with B-cell chronic lymphoblastic leukemia, preincubation with quercetin for 1-3 days resulted in significant sensitization to induction of apoptosis by DNA-topoisomerase II inhibitor vepeside. In Jurkat/А4 cells resistant to cytotoxic chemotherapeutic substances the sensitivity to apoptosis induction is reduced independent of apoptosis inducers used (cytotoxic drugs, polyphenols, ionizing radiation). Product Description popup.authors Завелевич Михайло Петрович Квілинська Анастасія Ігоревна Лупан Валентина Григорівна Фільченков Олексій Олексійович Шостак Катерина Олександрівна popup.nrat_date 2020-04-02 Close