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Information × Registration Number 0211U008116, 0109U008716 , R & D reports Title Prion-associative and no-prion-associative spongiform encephalopathy of the person: quantitative morphology and differential diagnostic. popup.stage_title Head Shlopov Valery Gennadievich, Registration Date 04-04-2011 Organization M. Gorky Donetsk National Medical University popup.description2 Retrospective it is carried out scrining revising of histilogicic preparations and the clinico-anatomic analysis of given 486 case of diseases and protocols of autopsy during lifetime of suffering spongiforme dementive encephalopathy. As material in final variant for a qualitative and quantitative evaluation of a morphological substratum CJD 174 cases of development progressing dementia with the morphological diagnoses have served: prion-аssociated spongiforme encephalopathy - 36, Alzheimer's disease - 67, Dementia with Lewy bodies - 19, vascular dementia - 52. The modern methods of morphological, histochemical of researches are used in work. Novelty of work consists that a criterion prion-аssociated spongiforme encephalopathy Creutzfeldt-Jakob is the set of morphological indications: loss of neurons, spongiosis, gliosis, presence prion-аssociated (PrP-Sc) deposists in remained neurons, astroglia, plaques, walls of vessels and spongioforme vacuoles in cortex and subcortex structures, hippocampus and a cerebellum at the absence of immune reactions, acute and chronic inflammation. Product Description popup.authors Волос Лілія Іванівна popup.nrat_date 2020-04-02 Close