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Information × Registration Number 0211U008266, 0110U004756 , R & D reports Title The role of ion exchange membrane processes in the regulation of cyclosporine- sensitive pore and free radical reactions in mitochondria popup.stage_title Head Sagach Vadym Fedorovych, Registration Date 21-04-2011 Organization Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 The critical role of exogenous cytochrome c in regulation of ROS production in mitochondria, dependent on the opening of mitochondrial permeability transition pore (MPTP) is studied. It is shown that most production of ROS induced by cytochrome c in outer space is located to the matrix and results from acceleration of Ca2+-cycling and oxygen consumption. Elimination of Ca2+-cycling by Ca2+-chelators at any stage of free-radical reactions and ROS formation abolishes ROS overproduction to control level observed in the absence of Ca2+. Product Description popup.authors Акопова Ольга Валеріївна Бурий Віталій Олексієвич Колчинська Людмила Іллівна Малишева Маргарита Костянтинівна Носарь Валентина Іванівна Сагач Вадим Федорович popup.nrat_date 2020-04-02 Close