Registration Number
0211U008266,
0110U004756
, R & D reports
Title
The role of ion exchange membrane processes in the regulation of cyclosporine- sensitive pore and free radical reactions in mitochondria
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Head
Sagach Vadym Fedorovych,
Registration Date
21-04-2011
Organization
Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine
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The critical role of exogenous cytochrome c in regulation of ROS production in mitochondria, dependent on the opening of mitochondrial permeability transition pore (MPTP) is studied. It is shown that most production of ROS induced by cytochrome c in outer space is located to the matrix and results from acceleration of Ca2+-cycling and oxygen consumption. Elimination of Ca2+-cycling by Ca2+-chelators at any stage of free-radical reactions and ROS formation abolishes ROS overproduction to control level observed in the absence of Ca2+.
Product Description
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Акопова Ольга Валеріївна
Бурий Віталій Олексієвич
Колчинська Людмила Іллівна
Малишева Маргарита Костянтинівна
Носарь Валентина Іванівна
Сагач Вадим Федорович
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2020-04-02
