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Information × Registration Number 0211U009104, 0106U005894 , R & D reports Title Condensed heterocycles of plant and synthetic origin in the synthesis of new types of bioregulators - the way to drugs of new generation popup.stage_title Head Volovenko Yu. M., Registration Date 24-06-2011 Organization Taras Shevchenko Kiev university popup.description2 Methods were developed for the synthesis of biomolecules based on bioactive heterocycles are such as pyrazole, imidazole, indole, izoindole, benzotiazepinone, benzimidazole, indolyzine, benzodiazepine, coumarin, chromanone, flavones, pyrimidine etc. These compounds were used as synthones for the targeted synthesis of new biologically active compounds. The results of biological research of modified flavonoids were compiled and most promising biomolecules for medical drug creation were selected. Methods were developed for the synthesis of new F-substituted alpha-amino acids on the basis of proline and glutamic and pipecolinic acids for structural studies via solid state NMR of peptides labeled with 19F-substituted amino acids in biomembranes and conformationally strained analogues of natural amino acids having a basic skeleton of cyclobutane, spiro[3.3]heptane, norbornane, and 1,2,3-substituted cyclopentane. Possibilities were studied for homogeneous hydrogenation of electron-deficit alkenes in general and flavonoids in particular. Methods were developed for obtaining of glycosides from a number of natural and synthetic coumarins, isoflavones and neoflavones. A number of cycloaddition adducts of 1-aminoizoindole and maleineimide derivatives were synthesized. A new rearrangement was discovered and product structure was proven via NMR and x-ray crystallography. The catalytic conditions were found for introducing souccineimide fragment to systems of pyridine, pyrazole, imidazole, pirydoizoindole, thiazole. Methods were developed for the synthesis of chiral dienophiles based on substituted maleineimides for reactions of asymmetric [2+4] cycloaddition. 2-Amino-3-hetarylspiropirolones were synthesized. A number of new derivatives of benzothiazines were obtained and their chemical properties were studied. The possibility was explored for using gamma-halogen-substituted alpha, beta-unsaturated aliphatic ketones for the synthesis of some nitrogen- and sulfur-containing heterocycles. Using these new methods, derivatives of pyrrole, indolizyne, pyrido[2,1-b]benzimidazole, imidazo[1,2-a]pyridine, [1,3]thiazolo[3,2-a]pyridine and triazolo[a ]azepine and their benzologs based on completing pirydine or azepine cycle were synthesized. A convenient method was developed for the synthesis of 3-(2-hydroxybenzoyl)-quinolines and 7H-chromen [3,2-c]-quinoline-7-ones in the presence of trimethylchlorsylane from 3-formylchromone and various amines. Modern methods of chemical, physicochemical research, modern methods of NMR spectroscopy, X-ray analysis were applied to prove the final structure of the synthesized compounds. Product Description popup.authors Єгорова Тетяна Володимирівна Бойко Олександр Миколайович Войтенко З. Воловенко Ю. Горбуленко Наталія Василівна Кисіль Андрій Іванович Коваленко Наталія Володимирівна Ковтуненко В. Комаров І. Кучеренко Тетяна Тимофіївна Москвіна Вікторія Сергіївна Попов Кирило Сергійович Потіха Людмила Михайлівна Ткачук Тетяна Михайлівна Туров Олександр Всеволодович Хиля В. Цапко Магдалина Дмитрівна Шабликіна Ольга Валентинівна Шилін Сергій Володимирович Шокол Тетяна Віталіївна popup.nrat_date 2020-04-02 Close