Registration Number
0211U009271,
0110U002412
, R & D reports
Title
To study the effect of transplantation of allogeneic cerebellum fetal cells on the course of acute trauma hemisphere of the cerebellum in the experiment.
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Head
Tsymbaljuk Vitalij Ivanovich,
Registration Date
12-10-2011
Organization
The state institution "Institute of neurosurgery n. acad. A. Romodanov AMS Ukraine"
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Object of study: Severe traumatic injury of the cerebellum. Objective: To examine the effect of transplantation of embryonic nervous tissue (TENT), transplantation of olfactory bulb tissue (TOBT) during the regeneration process in the CNS after traumatic injury of the cerebellar hemisphere in the experiment. Methods: Experimental, morphological, immunological, statistical. Results. In a study of restorative effect of allogeneic transplantation of fetal cells of the cerebellum and kidney, and olfactory bulb after modeling the local dose traumatic injury left hemisphere of the cerebellum. Scientific novelty of the research results is to improve the models of traumatic injury of the cerebellum, the study of the effect of TENT and the restoration of TOBT finktsy motor areas after traumatic injury of the cerebellum, especially studied the influence of TENT and TOBT on the dynamics of pathological changes in the injury of the cerebellar hemisphere, a comparative analysis of the impact of these two methods rehabilitation injury of the cerebellum, especially studied the influence of damage to the cerebellar hemisphere, and TENT TOBT in the injured area on the immune system of experimental animals, the study of the effectiveness of these methods of restorative treatment of acute trauma hemisphere of the cerebellum, the definition of its possible mechanisms. Presents the results convince us that the transplantation of allogeneic fetal tissue cerebellum gives reliable positive effect on the functional level. Expected efficiency of implementation. The findings suggested pathogenetic substantiation of the possibility of clinical use of the method neurotransplantation for rehabilitation consequences of traumatic lesions of the cerebellum.
Product Description
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Васлович Вікторія Вікторівна
Гнєдкова Ірина Олександрівна
Лiсяний Микола Іванович
Медведєв Володимир Вікторович
Семенова Віра Михайлівна
Сенчик Юрій Юрійович
Стайно Лариса Петрівна
Цимбалюк Віталій Іванович
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2020-04-02
