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Information × Registration Number 0211U009459, 0111U008360 , R & D reports Title The development of new approaches to the synthesis of medium azacycles annulated with aryl (hetaryl) fragment popup.stage_title Head Tolkunov Sergey Volodimir, Registration Date 20-12-2011 Organization The L.M.Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry popup.description2 Object of research - medium azacycles annulated with aryl (hetaryl) fragment, which contain heteroatoms of oxygen, nitrogen and sulfur. The purpose of work - development of methods of synthesis and updating of structures tetrahydrobenzothieno[2,3-c]azepines, azicines, thienо[2,3:5',4']thieno[2,3-с]pyridines by use of Pictet-Spengler reaction. Metods of research - methods of organic synthesis, mass- and NMR - spectroscopy, X-ray analysis. Cyclization of benzothienyl-3-propylamines in conditions of Pictet-Spengler reaction is investigated. New derivatives of tetrahydrobenzothieno[2,3-c]azepines of azepines is synthesized. A new strategy for the synthesis of the eight-membered heterocyclic skeleton of tetrahydroquinazolino[3,2-c][2,3]benzodiazocin-15-ones, based on the Pictet-Spengler reaction of 3-amino-2-[2-(3,4-dimethoxyphenyl)ethyl]quinazolin-4(3H)-one with carbonyl compounds in acidic media, is proposed. The new method of synthesis unknown earlier tetrahydrothienо[2,3:5',4']thieno[2,3-с]pyridines, which is based on interaction thieno[2,3-b] thieno- 3-ethylamine with aromatic aldehydes is developed Proceeding from the experimental data the comparisons of formation to six and seven- membered cycles condensed with benzothiophen and benzol in conditions of Pictet-Spengler reaction are carried out. The results of work can be utilised in organic chemistry, for synthesis of biologically active compounds, for creation of new drugs Product Description popup.authors Ереско О.Б. Земская Е.О. Толкунов В.С. Хижан О.І popup.nrat_date 2020-04-02 Close