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Information × Registration Number 0211U013261, 0110U004751 , R & D reports Title Investigation of molecular basis of potassium channel modulator action as neuroprotective agents during hypoxia popup.stage_title Head Lukianetz Olena Oleksandrivna, Registration Date 12-01-2012 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Measuring of intracellular calcium and recording of membrane potential by microfluorescent and electrophysiological methods we used to find the role of membrane voltage-dependent K +-channel blockers in the neuroprotection during hypoxia. During the reporting period the measurements of integral potassium currents of hippocampal neurons and PC12 cells exposed to chemical hypoxia were carried out. The role of these channels when exposed to hypoxia was tested with blockers K+-channels - 4-AP and TEA, which selectively inhibit the activity of Kv1.4 and Kv3 channels respectively. Conducted molecular biological studies potassium channels Kv1.2 expression in type cell line PC12. Product Description popup.authors Богданова Наталія Олександрівна Лук'янець Ігор Олександрович Лук'янець Олена Олександрівна Магура Ігор Сільвестрович Яворський Володимир Антонович popup.nrat_date 2020-04-02 Close