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Information × Registration Number 0211U013262, 0110U004756 , R & D reports Title The role of ion exchange membrane processes in the regulation of cyclosporine- sensitive pore and free radical reactions in mitochondria popup.stage_title Head Sagach Vadym Fedorovych, Registration Date 12-01-2012 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 The influence of mitochondrial pore opening on ROS generation in mitochondria is studied. It is established that the influence of pore opening on ROS production is controlled through membrane potential regulation, transmembrane ion exchange and respiration rate of mitochondria. The decreasing of ROS production due to pore opening at stationary conditions is the result of partial membrane depolarization. The important physiological function of the pore is stated that consists in supporting of low matrix Са2+ and decreasing ROS production due to partial membrane depolarization. Product Description popup.authors Акопова Ольга Валеріївна Бурий Віталій Олексієвич Колчинська Людмила Іллівна Малишева Маргарита Костянтинівна Маньковська Ірина Микитівна Носарь Валентина Іванівна Сагач Вадим Федорович popup.nrat_date 2020-04-02 Close