Registration Number
0211U013262,
0110U004756
, R & D reports
Title
The role of ion exchange membrane processes in the regulation of cyclosporine- sensitive pore and free radical reactions in mitochondria
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Head
Sagach Vadym Fedorovych,
Registration Date
12-01-2012
Organization
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine
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The influence of mitochondrial pore opening on ROS generation in mitochondria is studied. It is established that the influence of pore opening on ROS production is controlled through membrane potential regulation, transmembrane ion exchange and respiration rate of mitochondria. The decreasing of ROS production due to pore opening at stationary conditions is the result of partial membrane depolarization. The important physiological function of the pore is stated that consists in supporting of low matrix Са2+ and decreasing ROS production due to partial membrane depolarization.
Product Description
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Акопова Ольга Валеріївна
Бурий Віталій Олексієвич
Колчинська Людмила Іллівна
Малишева Маргарита Костянтинівна
Маньковська Ірина Микитівна
Носарь Валентина Іванівна
Сагач Вадим Федорович
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2020-04-02
