Search academic texts

Information × Registration Number 0212U000257, 0109U002167 , R & D reports Title To study clinical, morfofunkcional''nye and laboratory indexes at bronkholegochnoy pathology for children depending on a flow and phase of illness popup.stage_title Head Antipkin Y.G., Registration Date 07-02-2012 Organization State organization "Institute of pediatrics, obstetrics and gynecology NAMS of Ukraine" popup.description2 According to modern positions, ethiopathogenic mechanisms of contemporary forms of RB and ChB in children were researched, and basic criteria of diagnosis were formed, mechanisms of formation of damage of lung elasticity and braking of reparative processes in bronchial mucous membrane were researched. At the first time, based on dynamic morphological research, defined features of pathogenetic mechanisms of regenerative processes in respiratory system of children with different broncho-pulmonary pathology dependent on course and stage of disease, approach to diagnostics of early manifestations of forming of chronic broncho-pulmonary pathology in children were described. During this research was proved, that changes in degradation of extracellular matrix, connected with changes in expression of macrophages and expression of matrix metaloprotheinaze and interaction of them, lead to changes in regenerative prosess with further chronisation of inflammatory prosess and activation of sclerotic and fibrotic prosesses in bronchial structure. Was proved, that degree of development of apopthosis in cilliar epithelial cells may be an indicator for prediction of transformation of easy cases of RB in more complicated transitional forms. Was proved that indicator of chronisation of broncho-pulmonary prosess is reduction of quantity of normal cells of cilliar epithelium for 20% and increase of quantity of dystrophically changed cells for 80%, that lead to inability of mucous membrane to carry protective function as a result of deep cytomorphologycal changes in it. Was revealed, that in BA expression of apopthosal antigens is higher than in recurrent obstructive bronchitis, and expression of its regulators, that control phase of DNA degradation is lower, that promote deeper damage of regeneration of epithelial structures of bronchial tree with development of pneumosclerotic prosesses. Was proved, that definition of level of expression of apopthosal receptors of eosinophiles have prognostic value in BA therapy. Scientific newness - proved high effectiveness of optimization of basic BA therapy with antioxidative-antihypoxic drugs for correction of desadaptive immune-allergic-methabolic connections. At the first time was observed interconnection of expression of mRNA, synthesis of proteins and expression of enzymes of antioxidative protection of children with BA and proved an ability of its use as marker of effectiveness of interval hypoxic training (IHT). Was proved that analysis of expression of mRNA genes of antioxidative enzymes can be used as biomarker of oxidative stress in changes of effort of oxygen regime, that have practical meaning for individual widening of basic therapy. Gravity of clinical course of BA associate with presence of functional defective allels of glutation-S-transferase M1 and N-acetyltransferase 2, that can be used for prognosis of clinical course and development of reasonable therapy at early stages of disease. Was proved , that IHT improve respiratory lung function and increases effectiveness of circulatory functions, it decreases dysfunction of cellular methabolic prosesses with increasing of energetic potential of cells and activation of reserved mechanisms, increases firmness to hypoxic states, lead to positive clinical dynamics. Practical mean of this work is, that on the basis of modern diagnosis, proved mechanisms of formation of disorders in lung elasticity with further sclerosis of lung tissue and causes of braking of reparation of bronchial mucosa helped to find drugs which is aimed to activate processes of reparation of bronchial mucosa, that can reduce duration of inflammatory prosess and can prevent a development of peribronchial pneumosclerosis, that is morphological substrate of next relapses with transformation in ChB of adults. Was shown, that diagnosis of bronchial hyperreactivity is necessary to use for discharge of risk groups of transformation of acute process in chronic with further usage of prophylactic methods. Was proved, that investigation of detoxicative systems has practical mean in diagnosis of formation and prognosis of course of bronchobstructive syndrome with reducing of activity of enzymes of 2 phase, metabolites of 1 phase of detoxication are not utilized, they can provoke degranulation of fat cells in respiratory tract, that leads to release of wide spectrum of bioactive substances. This may cause inflammation in bronchi and increase of its hyperactivity. Definition of syndrome of bronchial hyperactivity as hidden phase of disorder of bronchial passability can be used for discharge of risk groups of passage from acute to chronic process. Proved diagnostical and differential-diagnostical means of non-invasive method of investigationof condensate of expiratory air - its aminoacid contents in recurrent, chronic non-specific lung diseases in children. Was shown that individual hypoxic training can be used for prevention of recrudescence in BA. Was proved that definition of protein and mRNA antioxidative enzymes expression can be a marker of effectiveness of individual hypoxic training in BA in children. For differential diagnosis of recurrent and chronic bronchitis and bronchial asthma in children investigation of sick In conditions of specialized pulmonary department with addition to standart circuitry of examination clinic-anamnestic data in scores assessment is recommended. Changes of indicators of aminoacids in expiratory air condensate, simultaneously with dynamics of clinical symptoms of recurrent and chronical bronchitis and bronchial asthma can be additional criteria for establishment of diagnosis and control of effectiveness of rehabilitative measures. Developed cytological, immunocytochemical and ultrastructure criteria can be used for selection of methods of treatment of children with chronic inflammatory diseases of respiratory organs. One of the cytologic criteria is characteristic of changes in bronchial epithelium in brash-biopsy. Relevation of dysthrophic changes and cells of inflammatory infiltration prevailed in brash-biopsy in children with chronic and recurrent bronchitis. Usage of multyprobiotic in complex treatment of children with non-specific lung diseases promote positive dynamics of immunological characteristics, and to improvement of general condition of sick children and to decrease of manifestation of clinical symptoms of mentioned diseases. Investigations gave proof of necessity of additional therapy of children with recurrent and chronic bronchitis and bronchial asthma with course of probiotics. Product Description popup.authors Арабська Л.П. Задорожна Т.Д. Несвітайлова К.В. Пустовалова О. Радченко Н.О. Смірнова О.А. Толкач С.І. popup.nrat_date 2020-04-02 Close