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Information × Registration Number 0212U000514, 0110U000231 , R & D reports Title To reveal the pathogenetic pathways of diabetes mellitus in Chernobyl NPP accident survivors exposed to ionizing radiation in dose range of 0.25-7.1 Gy popup.stage_title Head Kovalenko Alexander Nikolaevich, Registration Date 16-02-2012 Organization Research Centre for Radiation Medicine popup.description2 The fraction of persons who had fallen ill with diabetes mellitus was larger among the ARS convalescents vs. the ChNPPA clean-up workers exposed to radiation within 0.25-0.9 Gy absorbed dose range. DM origination and progressing appeared being linked to hyperinsulinemia, age of the patient and hypercholesterolemia. The age, hyperinsuilinemia, body mass index and serum cholesterol concentration had defined (in the sequence of importance) the risk to sicken with DM within 25 year survey period since exposure to radiation in ARS convalescents and ChNPPA clean-up workers having no signs of marrow failure. Structural abnormalities of pancreas in ChNPPA survivors were shown as indicating to the lowering of functional capacity of -cells and therefore implying lack of insulin and onset of DM type 2. High prandial and postprandial glycemia levels after the food stimulation in ChNPPA clean-up workers ill with DM resulted in a substantial increase of serum proinsulin concentration against no increase of C-peptide concentration. The latter mans combination of insulin resistance and lack of insulin in those patients despite compensatory hyperinsulinemia was revealed some years before. Significant increase of the postprandial glycemia along with elevation of C-peptide, insulin and prionsulin concentrations occurred at that in population of contaminated territories and persons not exposed to radiation. The DM type peculiar with a decreased insulin secretion and abnormal proinsulin conversion to insulin is more prevalent in ChNPPA clean-up workers vs. inhabitants of contaminated territories or persons not exposed to radiation. In such a variant no obesity grade II-III is typical along with the presence of an increased postprandial glycemia, dyslipidemia and required administration of insulin as a single agent therapy or combined management aiming compensation of DM. Disorders of protein metabolism were found along with carbohydrate and lipid metabolic disorders particularly in ARS survivors. Signs of a concentric LV myocardial hypertrophy occur in them at the background of intensified synthesis of collagen type I in extracellular matrix vs. the ChNPPA clean-up workers of 1986 period in whom such abnormalities are linked to depression of its degradation. Product Description popup.authors Афанасьєв Дмитро Євгенович Білий Давид Олександрович Камінський Олексій Валентинович Копилова Ольга Василівна Чикалова Ірина Григорівна popup.nrat_date 2020-04-02 Close