Search academic texts

Information × Registration Number 0212U000557, 0110U004758 , R & D reports Title Pharmacological modulation of excitation-inhibition mechanisms of smooth muscle in norm and pathology. popup.stage_title Head Shuba Yaroslav Myhaylovych, Registration Date 17-02-2012 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Detected the ability of peptidoglycan cell wall of Staphylococcus aureus increase the contractility of smooth muscle myometrial estrogen-treated and pregnant rats. Revealed that the peptidoglycan increases myometrial contractility due to formation of platelet activating factor, which stimulates production of inositol phosphates and activates the PI3K / ERK ? / p38 MAK metabolic pathways in rat myometrial SMC. Platelet activating factor can play a role as one of the factors of induction of premature birth caused intrauterine staphylococcal infection. Product Description popup.authors М.В. Кустов Є.М. Кулієва І.А. Владимирова І.Б. Філіппов В.В. Рекалов В.Г.Найдьонов Д.В.Гордієнко К.М. Суханова О.В. Повстян О.М. Цугорка Ю.Б. Дискіна Я.М. Шуба popup.nrat_date 2020-04-02 Close