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Information × Registration Number 0212U000616, 0108U010141 , R & D reports Title Genetic aspects of malignant tumors in children and young people in Western Ukraine popup.stage_title Head Hnateyko Oleh, Registration Date 01-03-2012 Organization Scientific-research institute of Hereditary pathology popup.description2 The frequency of GSTM1 + genotype in the group of women with breast cancer significantly lower (P <0,05), compared with controls and is 4 (13.3%) cases against 85 (54%). Note the relatively high frequency of variant genotype GSTM1-in this group - 26 (86.7%), whereas in the control group revealed 72 (46%) cases of the specified genotype. In the group of women with breast cancer and mothers who gave birth to a child with ALL was associated, genotype GSTT1-occurs significantly less (P <0,05) compared with control group. There is a low frequency of variant genotype CC polymorphic locus C481T gene NAT2 in the group of children with acute leukemia and in a group of women with breast cancer (P <0,05). In mothers of children with ALL was associated variant genotype AA locus gene NAT2 G590A met significantly more often (P <0,05) compared with controls, while in women with breast cancer the frequency of genotype AA was significantly lower (P <0,05). Among children with ALL was associated observed significantly higher frequency of genotype GA polymorphic locus gene NAT2 G590A compared with control (P <0,05). GG genotype polymorphic locus A803G gene NAT2 uzhinok with breast cancer was significantly lower (P <0,05) compared to control. Women with breast cancer variant genotype GA polymorphic locus gene NAT2 G857A met significantly more often (P <0,05) compared with controls, while in mothers of children with ALL was associated frequency of this genotype was significantly lower (P <0,05). In 30 families residing in the Dolyna, malignant tumors were found in 8 (26.7%)families. In 30 families residing in the village. Kalush - in 10 (33.3%) families. The spectrum of malignant tumors (1 to 6 cases) in both groups was extensive - cancer of the lungs, internal organs, breast, cervix, sarcoma of bone cancer, throat, nose, intestines, lungs and skin. Product Description popup.authors Акопян Гаяне Рубенівна Віштак Наталія Валентинівна Віштак Наталія Валентинівна Гельнер Надія Володимирівна Гнатейко Олег Зіновійович Кіцера Наталія Іванівна Лозинська Марія Ростиславівнв Маркевич Наталія Володимирівна Чорна Лілія Богданівна popup.nrat_date 2020-04-02 Close