Registration Number
0212U001186,
0107U010156
, R & D reports
Title
Optimization of the system of observation by population immunity of Ukraine inhabilitans againts diphtheria and tetanus by the way of creation of informational network regional and national levels
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Head
Hladka Olena,
Registration Date
23-01-2012
Organization
State Institution "Lviv Research Institute Epidemiology and Hygiene Ministry of Health of Ukraine"
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The aim of work -improvement of the system of monitoring the herd immunity against diphtheria and tetanusin Ukrainian population through the development and implementation of computer software, monitoring the circulation of the Corynebacterium diphtheriae with the study of its sensitivity to antibiotics. Methods of research: epidemiological, serological, statistical, bakterіologicаl. The long-term downward trend in the overall level of disease and carriage of the causative agent of diphtheria and the lack of fatalities was shown. However, in 2011 recorded an increase in the incidence of diphtheria and tetanus, diphtheria carriage in children. During 2008-2011, showed a significant reduction in the level of coverage and the reduction of immunity against diphtheria, the most pronounced in children 1-6 and 12-13 years. A computer program on a Linux system to create an electronic database on the intensity of immunity against diphtheria and tetanus was created; developed training materials for improving the monitoring system for herd immunity. Electronic databases with the immunity of individual regions and the total population for 2007 - 2010's were formed. The complex of research and study methodology to determine the background level of the circulation of Corynebacterium diphtheria among healthy population. A molecular-genetic typing of isolated in the western region of Ukraine C. diphtheriae strains by PCR with universal and specific primers was carrier; revealed a significant prevalence of latent gene tox. For the first time determined the structure of the C. diphtheriae population in their sensitivity to bacteriostatic and bactericidal action of penicillin. A method of indicating strains tolerant to penicillin was developed. Research results incorporated into the draft guidelines, information sheets 2, 6, informational and analytical certificates, 6 papers, 26 abstracts, 2 patents, 13 presentations at conferences.
Product Description
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Геник Ігор Дмитрович
Малова Ольга Сергіївна
Мотика Олена Ігорівна
Сіренко Іванна Семенівна
Чумаченко Світлана Семенівна
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2020-04-02
