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Information × Registration Number 0212U001188, 0109U001234 , R & D reports Title To improve of diagnostic and prognosis course of premalignante diseases of upper airways popup.stage_title Head Zabolotnyy Dmitro I., Registration Date 24-01-2012 Organization Kiyv Research Institute of Otolaryngology named after prof. O.S.Kolomiychenko popup.description2 The features of the clinical course of chronic inflammatory and productive (pre-cancerous) diseases of the upper respiratory tract. Research findings enabled the development of a diagnostic algorithm for evaluating patients pre-cancerous diseases of the upper respiratory tract. Studies have systemic immunologic reactivity of patients precancerous lesions of the upper respiratory tract disorders revealed a number of indicators of cellular and humoral immunity. According to postmortem studies and retrospective analysis of existing material is determined a high risk of metaplasia tumors of the nose and paranasal sinuses. The scheme of treatment of patients with precancerous antirecurrent upper respiratory tract infection on the basis of preliminary clinical and laboratory research and a diagnostic algorithm. The efficiency of the developed scheme based on an analysis of clinical, biochemical, immunological and morphological studies of the dynamics of treatment. According to biochemical studies of the growth and proteolytic activity of fibrinogen may be a reflection of the presence of the organism in patients with inflammatory process. After treatment the obtained data show different trends of changes of blood indices in blood plasma of patients pre-cancerous diseases of the upper respiratory tract, which requires further study and research on a larger statistical material. The obtained data from clinical trials demonstrate a high effectiveness of the proposed treatment regimen, which contributed to the normalization of most changes in the indices of the immune system of patients. Product Description popup.authors Голобородько Ольга Петрівна Заяць Тетяна Кікоть Юлія Володимирівна Клочков Євген Іванович Костюченко Олександр Леонідович Кривохатська Людмила Дмитрівна Савченко Таміла Дмитрівна Самбур Марина Борисівна Сидоренко Тетяна Тимченко Марина Дмитрівна Тимченко Сергій Вадимович popup.nrat_date 2020-04-02 Close