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Information × Registration Number 0212U001431, 0110U000233 , R & D reports Title Study to ability of the long-term treatment by antihypertensive drugs in clean-up workers after Chernobyl disaster with essential hypertension and developing of the new approaches for the optimization to prevention/regress myocardial hypertrophy popup.stage_title Head Khomazjuk Inna, Registration Date 03-02-2012 Organization Research Centre for Radiation Medicine popup.description2 Study subjects The 125 Chornobyl disaster clean-up participants (ChDCUP) suffering an arterial hypertension (AH) upon the time of survey and 30 AH patients not exposed to ionizing radiation. Study objective Estimation of organoprotective capacity of the first-line antihypertensive drugs regarding LV hypertrophy and dysfunction in Chornobyl disaster clean-up participants suffering AH according to results of the two-year survey. Methods Clinical, radiation impact analysis, other risk factor analysis, blood pressure (BP) daily monitoring, electrocardiography, heart rhythm variability assay, echo Doppler cardiography, cycle ergometry. Results The organoprotective properties of the first-line antihypertensive drugs were revealed focussed at regression of LV hypertrophy and dysfunction in ChDCUP suffering AH. The effects of ACE inhibitors were compared to ARBs in monotherapy and in combination with diuretics or calcium channel blockers, that provided a robust round-the-clock control of BP, significant lowering of an average daily and nighttime systolic and diastolic BP, decrease of BP variability and daily index normalization. Combined medication was proven as providing more significant tolerance of physical load vs. monotherapy. Under the comparable effect of stated combinations a couple of weeks term had favored only the retardation of LV hypertrophy (LVH) progression being however not capable for the LVH regression. Under the long-term treatment when both systolic and diastolic BP remained at a target levels the LVH regression occurred. The decrease of myocardial mass index (MMI) was reached in one year for 8% after the enalapril administration, for 10% after perindopril and combination of enalepril with amlodipine, for 10.9% in recipients of perindopril combination with indapamid, and for 11.8% as a result of losartan combination with hydrochlorthiazide. No any case of LVH progression occurred in those patients within survey period unlike cases of medication withdrawal. Improved diastolic function was found both after monotherapy and combined medication. Increased ratio of relative maximum velocities of early and late diastolic filling was registered since the week 4 reaching a significant difference in 12 months being 31.5% vs. baseline values. Reliable decrease of time of myocardial isovolumic relaxation was registered too. Recovery of abnormal diastolic function occurred under medication earlier than LVH regression. LVH regression was found requiring a regular management for an inexplicitly long time. Advantages of ACE inhibitor and ARB effects regarding the regression of LVH and LV dysfunction were revealed through the conducted analysis of organoprotective properties of the first-line antihypertensives. The useful model was elaborated (certificate of acceptance № u2011 12860 by 2.11.2011). Effectiveness Organoprotective effect of the first-line antihypertensives have been identified towards regression of LVH and LV dysfunction in ChDCUP suffering AH. The useful model for prevention of LVH complications was elaborated. The study results were published in 15 papers and presented in 4 reports. Product Description popup.authors Габулавічене Жанна Михайлівна Курсіна Наталія Вікторівна Сидоренко Геннадій Васильович popup.nrat_date 2020-04-02 Close