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Information × Registration Number 0212U001591, 0109U001720 , R & D reports Title Vertebral pain syndrome in elderly people with systemic osteoporosis: mechanisms of development, diagnosis, prevention and treatment. popup.stage_title Head Povoroznjuk Vladislav V., Доктор медичних наук Registration Date 14-02-2012 Organization State Institution "Institute of Gerontology AMS Ukraine" popup.description2 Aim - to study the mechanisms of development, particularities of the diagnosis, prevention and treatment of vertebral pain syndrome in elderly people with systemic osteoporosis. Methods: the orthopedic examination, questionnaires (Scale VAS, EuroQol-5D, Roland-Morris, Ecos-16, 1-min. test IOF, fractures form); anthropometric studies, dual-energy X-ray absorptiometry (spine, forearm, femur, total body, body composition), X-ray of thoracic and lumbar spine, followed by X-ray morphometry, ultrasound densitometry; X-ray of hand, bone turnover markers in blood serum. Results: it was proved that the frequency and severity of vertebral pain syndrome significantly increases with age in women - at the level of the thoracic since 60-69 years, lumbar - since 70-79 years old, and accompanied with a deterioration in quality of life. In men, it wasn't found correlation between the pain severity and quality of life depended on the age. In women with osteoporosis, the severity of vertebral pain, indexes of functional activity and quality of life were significantly worse than in men with osteoporosis. The severity of the pain in the thoracic and lumbar spine didn't depended on the age in women with osteoporosis. In women with osteopenia and normal bone mineral density (BMD) it was found a significant higher pain syndrome in the thoracic and the lumbar spine and the deterioration of the quality life since 60 years. In patients with vertebral pain syndrome the frequency of osteoporotic fractures increases with age, from 18% at 40-49 years to 50-54% at 70-80 years old. Low-energy fractures were detected in 71% of women with osteoporosis, 43% - with osteopenia, 41% - with a normal BMD. In postmenopausal women with low-energy fractures was found significantly higher intensity of pain syndrome in patients with osteopenia and osteoporosis. In women without low-energy fractures the severity of pain syndrome and quality of life does not depended on the structural and functional state of the DMD (osteoporosis, osteopenia, age norm). Vertebral pain syndrome occurs in all types of vertebral deformities, but its expression is greater in patients with compression fractures. It was revealed the association between the severity of pain syndrome, quality of life indexes and the frequency and severity of deformities in the thoracic spine. Women with fractures of the vertebral bodies, or a combine fractures, have a significantly higher level of pain in the thoracic spine and significantly poorer performance of functional activity. Vertebral pain syndrome was significantly higher in compression fractures of the thoracic spine or in case three vertebrae fractures in the lumbar spine. Application of a new generation of bisphosphonates (alendronate and pamidronate) in patients with systemic osteoporosis leads to a significant decreasing the severity of vertebral pain syndrome and stabilization or improvement of BMD of the axial skeleton. Product Description popup.authors Балацька Наталія Іванівна Бистрицька Марина Анатолівна Григор'єва Наталія Вікторівна Дзерович Наталія Іванівна Дубецька Галина Сергіївна Креслов Євгеній Олександрович Орлик Тетяна Василівна Поварознюк Василь Валерійович Юнусова Світлана Вікторівна popup.nrat_date 2020-04-02 Close