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0212U001593,
0109U001718
,
To explore age-related peculiarities of the brain injury pathomorphosis and to evaluate the criteria of the effectiveness of pathological changes correction
Kvitnitzkaya-Ryzhova Tatiana Yurievna,
14-02-2012
State Institution "Institute of Gerontology AMS Ukraine"
Traumatic brain injury (TBI) is characterized by impaired hippocampal cytoarchitectonics with the development of destructive and dystrophic changes in neurons, glia, capillaries. Hydropic disorders were the most representative, visualized in the swelling of individual organelles (mitochondria more frequently), and parts of cells (axons, astrocytic feet) and even whole neurons and gliacytes; dystrophic disorders have resulted in significant deposition of lipofuscin and the residual cells; significant changes of myelin, until its disaggregation, disorder of lamellar structures, the forming of swellings and evaginations. The morphometric analysis showed the significant decrease in the number of neurons and changes in the population of neurons - the growth of hyperchromic destructive forms by reducing the number of unmodified ones as well as the significant increase in the number of macroglia and 4-fold increase in the number of microgliacytes in TBI. Gene therapy, namely the liposomal transfection of CNS cells with plasmid vectors, carrying the gene apoE3 for human, which positively affects the hippocampal structure and ultrastructure - it decreases brain injury-induced neuronal death and improves their qualitative composition, reduces axonal damage and destruction of myelin, gliosis and microglial reaction, pericapillary edema and accumulation of lipofuscin. The fluorescent immunohistochemistry data, obtained by confocal microscopy, confirmed the loss of neurons in the hippocampus in TBI, the presence of gliosis and indicate the activation of neuron-glial relationship (there are hypertrophy of the bodies of astrocytes, the increase in the number of branches, change in their focus and increase embranchment and the contact area between neurons and glia). Gene therapy has helped to reduce the destructive and degenerative changes in the brain tissue caused by TBI, reduced gliosis, the normalization of the astrocytes structure, increase in the number of small neurons in the radial zone of the hippocampus, which may indicate the beginning of neurogenesis. Thus, for the objective assessment of the impact of gene therapy on pathological consequences of TBI, we believe it appropriate to use in a complex calculation of the number of neurons and gliocytes and determination of apoptotic index, the definition of the qualitative composition of neurons and assessment of neuron-glial relations, determination the state of axons, and capillaries.
Балла Ірина Анатоліївна
Квітницька-Рижова Тетяна Юріївна
Малишева Світлана Петрівна
Матвієнко Марія Григорівна
Михальський Сергій Анатолійович
2020-04-02
Updated: 2026-01-13
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