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Total number
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0212U001596,
0109U001719
,
Determination of the patern of prevention of thrombotic acident from the position of plateles hemostasis for elderly people with IHD
Korkushko Oleg Vasilievich, Доктор медичних наук
14-02-2012
State Institution "Institute of Gerontology AMS Ukraine"
The target. Identify features of the prevention of thrombotic complications from a position of platelet hemostasis in patients with coronary heart disease over 60 years. The object.Healthy people 20-29 years, 60-79 years, elderly patients (60-79 years) with coronary artery disease (I-II ССS, NYHA-0-I). Methods. Laser Doppler flowmetry, agregatometriya, viscosimetry, ELISA, gazohromatografiya, coagulometer. The results. In the esearch is shown that with aging observed platelet activation of hemostasis: increased platelet aggregation activity, the weakening of anticoagulant and fibrinolytic activity in the background of changing the balance of vasoactive substances synthesized by endothelial cells with a predominance of vasoconstrictors, which is associated with age-related increase in blood viscosity, increased free radical activity, increases levels of inflammatory cytokines, changes in lipid and fatty acid composition of cell membranes. It was shown that violation of fatty acid composition of platelet membranes may be one of the mechanisms of aspirin in elderly patients with coronary artery disease. To restore the "answer" records to aspirin in these patients may be effective prescribing omega-3 PUFAs in a dose of 1000 mg / day rate for 3 months. The development of secondary aspirin was associated with progression and destabilization of coronary flow, as evidenced by changes in clinical disease (increase in frequency and duration of angina attacks and their equivalents), the appearance or increase the severity of edema, shortness of breath, increasing the duration of ischemia time daily according to the daily monitoring ECG. Industry use. Preventive and clinical medicine, gerontology, internal medicine, cardiology. Forms of implementation. Patents, guidelines, articles, reports.
Бодрецька Лариса Анатоліївна
Лишневська Вікторія Юріївна
Самоць Ірина Анатоліївна
2020-04-02
Updated: 2025-12-07
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