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Information × Registration Number 0212U002184, 0109U001569 , R & D reports Title Determination of the chronical coronary heart disease follow-up peculiarities, structure of the associated diseases, risk stratification in clean-up workers after Chernobyl disaster and creation of the new approaches to prevention and treatment fight risk patients popup.stage_title Head Khomazjuk Inna, Registration Date 27-01-2012 Organization Research Centre for Radiation Medicine popup.description2 Subject of inquiry: 300 clean-up workers after Chernobyl disaster (CWCD) and 100 non-irradiated patients - control group. Methods: clinical, analysis of radiation exposure, other risk factors, daily monitoring of electrocardiogram (ECG DM), heart rate variability, the echodopplerechocardiography, bicycle ergometry. Goal: Defining of the clinical follow-up peculiarities of the stable angina pectoris, creating of the algorithm of risk stratification of complicated follow-up and new prevention and treatment approaches using for delay of disease progressing in CWCD. Results: Approaches to adequate treatment of CWCD with angina pectoris based on total risk conception, combined treatment that improve prognosis and lower ratio and intensity of angina attacks were substantiated. Total risk stratification algorithm and model of angina treatment in CWCD were elaborated. There was established angina attacks ratio and nitroglycerin using significantly lowering during treatment provided high compliance. Antiischemic and antiarrhythmic effects based on daily monitoring of electrocardiogram were established during hospital as well as all treatment period. Quantity and duration of ST-depression > 1 mm episodes were reduced in two times as well as asymptom ischemic episodes in 2.5 times. Indexes of total heart rate variability were increased after treatment. Vegetative balance was improved as well as sympathetic influence was diminished. Global and local myocardial contractility improvement took placed using basal model of treatment combined with cardiomyocytoprotectors. During treatment antioxidant system state was improved. Exercise tolerance was significantly increased during permanent treatment. In CWCD with angina pectoris and irradiated dose >25 sZv results of treatment were worse. In cases of high compliance to health life style treatment effect was worse. Permanent using of lipid lowering diet and statins promoted to lowering of cholesterol in high and very high risk patients. Stopping of tobacco smoking predominantly was in very high risk CWCD with angina pectoris. Opposite in non-regular treatment were worsening of clinical follow-up, electrocardiography, structural and functional myocardial indexes especially in very high risk patients. Efficacy: Determining of the adequate approaches to treatment of CWCD with angina pectoris its influence on ratio and duration of ischemic episodes, global and local myocardial contractility, left ventricle diastolic function, oxidative stress, exercise tolerance was substantiated long-term treatment, the adaptation of treatment to the patient, expanding the boundaries of the impact of factors of cardiovascular risk, early treatment. As a result of the work presented 39 publications, including guidelines, innovation patent, 15 reports. Product Description popup.authors Ковальов Олександр Сергійович Курсіна Наталія Вікторівна Настіна Олена Михайлівна Сидоренко Генадій Васильович popup.nrat_date 2020-04-02 Close