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Information × Registration Number 0212U004391, 0107U003005 , R & D reports Title Synthesis polycyclic nitrogen containing systems via cyclization and recyclization reactions popup.stage_title Head Bogza Sergej Leonidovich, Доктор хімічних наук Registration Date 09-02-2012 Organization The L.M.Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry popup.description2 Object of research - the average azatsykly, fused with hetarylnym (aryl) fragment containing heteroatoms oxygen, nitrogen and sulfur. The purpose of research - development of methods for synthesis and modification of structures izohinolinu, benzofuropirydynu, benzotiyenopirydynu and indolopirydynu using cyclization reactions and recycling. Methods - Methods of Organic Synthesis, mass and NMR spectroscopy, X-ray analysis. Methods of obtaining izohinoliniv, benzofuropirydyniv, benzotiyenopirydyniv and indolopirydyniv using acid-katlizovanyh tsyklizatsiy and recycling reactions in different experimental conditions. Have studied the cyclization of aryl (hetaryl) substituted amides and amino (hiroksy) maleyinimidiv under acid-katalizovanoho atsylyuvannya and oxidative cyclization, which led to the synthesis of new derivatives izohinoliniv, benzofuropirydyniv, benzotiyenopirydyniv and indolopirydyniv. New methods anelyuvannya five-and six-membered cycles in cycle pirydynovoho benzofuro and benzotiyenopirydyniv and functionally-substituted derivatives and condensed b-and g-karbolinu. First opened and investigated the reaction of salt recycling Dual 4-tsianoindolo [2,3-c] piryliya hydrazine, leading to new heterocyclic systems pyrazole [3 ', 4': 5,6] pirydo [3,4-b] indole. A new method of synthesis of previously unknown azolokondensovanyh benzazepiniv and 2,3-benzodiazepines, based on the interaction of benzyl (hetarylmetyl) aminoazoliv substituted with aromatic aldehydes in a Pictet-Spengler reaction. The results can be used in the preparative chemistry of heterocyclic compounds for the synthesis of biologically active compounds and new drugs. Product Description popup.authors Євтушенко Валентина Іванівна Єресько Олександр Борисович Вольвич Ганна Федірівна Дуленко Володимир Іванович Зінченко Софія Юріївна Земська Євгенія Олексіївна Кібальний Олександр Володимирович Кузнецова Ксенія Петрівна Попов Вадим Юрійович Попов Олексій Юрійович Сівякова Людмила Миколаївна Толкунов Андрій Сергійович Толкунов Валерій Сергійович Толкунов Сергій Володимирович Хабаров Константин Михайлович Хижан Олександр Іванович popup.nrat_date 2020-04-02 Close