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Information × Registration Number 0212U004745, 0110U006118 , R & D reports Title Antitumor drugs of new generation based on heterocyclic inhibitors of telomerase, specific ligands of quadruplex DNA. popup.stage_title Head Dubey Igor, Доктор хімічних наук Registration Date 25-01-2012 Organization Institute of molecular biology & genetics popup.description2 Synthetic methods were developed to obtain the series of new heterocyclic derivatives of cationic porphyrins, their Zn and Mn metallocomplexes and conjugates, hetaryl-substituted chromones, symmetrical and unsymmetrical tricarbocyanines, potential ligands of quadruplex DNA. Computer modelling of the structure of porphyrin conjugastes was performed using quantum-chemical method DFT. Elaboration of the TRAP test system for the analysis of telomerase activity in vitro has been started. Product Description popup.authors Ільченко Микола Миколайович Дубей Лариса Василівна Костіна Валентина Григорівна Костенко Олександр Миколайович Криворотенко Дмитро Валентинович Кузів Ярослав Богданович Негруцька Валентина Володимирівна Швед Анатолій Давидович popup.nrat_date 2020-04-02 Close