Registration Number
0212U006193,
0111U006259
, R & D reports
Title
New heterocyclic compounds - effective sources of biologically-active substances, fluorescent probes, modifiers of supramolecular objects
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Head
Volovenko Yu. M.,
Registration Date
01-03-2012
Organization
Taras Shevchenko Kiev university
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Report : 107 p., 80 рiсt., 3 tаbl., 1 addition., 89 references. Research object: nitrogen-, oxygen- and sulfurcomprising geterosystems. Work aim: The development and improvement of preparative methodes and methodics of synthesis of novel geterocyclic compounds for making of novel bioregulators of widespread-spectrum of range, novel photosensitive and fluorescent materials. Research methodes: Methodes of synthesis of model organic substances, geterocyclic substances; NМR-, IR-, UV-, fluorescent spectroscopy; mass- and chromatomass-spectroscopy; methodes of synthesis under high pressure and inert atmosphere; XR- and elemental analysis. The methodes of synthesis of novel sulfolane derivatives; series of modificated maleineamides with alifatic chains and aminoacide groups, novel bis-addition Mikhaele compounds with 1-aminoisoindole (1:2) and rearranged addition producte of II type, which has fluorescent properties; novel 8-оxoazolo[a]pyridine, 10-oxo- and 10-aminoazolo[b]isoquinoline and isoindolo[2,1-а]quinoxaline derivatives was worked out. The methodes of synthesis of novel 3,4-dihydrochroman-2-carboxilate with primary and secondary alifatic amines, 3-formyl-2H-chromen-2-carboxylate with geterylacetonitriles , cyclopencarboxylic acides, а-aminiacides with bicyclic nonbornane skeleton on the base of catepine and 4-camphorcarbocylic acides, cyclic anhidrides of catepine and 4-camphorcarbocylic acides and their futher transformation into aminoacides was worked out. The preparative methodes of synthesis getaryl-2-hydroxiacetphenones and pathway of their transformation into azaheterocyclic analogs was worked out. The series of novel aminomethyl-3-azagetarylchromone derivatives; 3-(get)aryl-7-hydroxi-8-formylchromone and 3-(2-quinolyl)chromone; terminal 3-azagetarylchromones and 2-R-3-azagetarylchromones, hard-to-reach С-substituted N-(phosphonomethyl)glycine derivatives, novel 1,1-bisphosphonic acides was synthesised. The effective methode of synthesis of similar to drugs compounds with nicotinic acide fragment was worked out.
Product Description
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Єгорова Т.В.
Бійцева А.В.
Бойко О.М.
Войтенко З.В.
Воловенко Ю.М.
Воловненко Т.А.
Кисіль А.І.
Коваленко Н.В.
Кучеренко Т.Т.
Москвіна В.С.
Пласконь А.С.
Попов К.С.
Потіха Л.М.
Ткачук Т.М.
Туров О.В.
Цапко М.Д.
Чекотило О.О.
Шабликіна О.В.
Шилін С.В.
Шокол Т.В.
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2020-04-02
