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Information × Registration Number 0212U006424, 0109U000944 , R & D reports Title Structure-functional investigation of the ligands of receptors central nervous system with the goal directed synthesis neurotropic remedies popup.stage_title Head Andronati Sergey Andreevich, Registration Date 28-03-2012 Organization Odesa I.I.Mechnikov national university.Pervomaisk institute. popup.description2 Obtained important theoretical and practical results on the role of nitrogen heterocycles as terminal fragment in substituted arylpiperazines - buspirone analogues. It is shown that their role in the formation of supramolecular complexes between these ligands and 5-HT1A serotonin receptors. For obtained compounds studied the anxiolytic activity and affinity for 5-HT1A receptors. Founds the derivatives of thiopyrimidine and endic imide with anxiolytic activity greater than refrens-drug buspirone. First to show that arylpiperazines containing thiopyrimidines as substituent also exhibit high actoprotector activity in the doze 1 mg/kg. In a series of 5-alkyl-2-(b-morpholinoethyl)mercapto-3,4-dihydropyrimidine-6-ol-4-ones found effective and antihypoxants and actoprotectors exceeding the activity mebikar. Studied of the dependence of the "structure-pharmacological activity-affinity". For further studies as anxiolytics, actoprotectors and antihypoxants proposed a number of compounds containing thiopyrimidine, phthalimide, theophylline, endic imide. Product Description popup.authors Ганевич Віктор Миколайович Карасьова Тамара Леонідівна Смульський Сергій Петрович Соболєва Світлана Григорівна Фельдман Семен Вікторович popup.nrat_date 2020-04-02 Close