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Information × Registration Number 0212U008216, 0110U006128 , R & D reports Title Development of fundamentals methods rof cell therapy of heart pathologies popup.stage_title Head Lyubov L. Lukash, Доктор біологічних наук Registration Date 04-12-2012 Organization Institute of Molecular Biology and Genetics popup.description2 During the reporting period continued to study the role of cardiospecific embryonic deletions of b-catenin gene in the development and formation of the adult myocardium. Analysis of the frequency distribution of genotypes in newborn animals showed that animals with genotype b-cat flox / wt; Cre (СКО) were born with frequency by splitting genes Mendel. In the analysis of experimental animals aged 1, 3 and 6 months, we did not observe increased mortality of mice with embryonic deletion of one allele of the gene b-catenin. Morphological analysis of tissue infarction udalt animals aged 1, 3 and 6 months revealed no violations formation of heart tissue fibrosis or other (HE and MT staining). As a result of the work we have observed an increase in gene expression of hypertrophic response ANP, BNP, b-MHC and reducing expression of myosin adult cardiac a-MHC in mutant females and males compared to control. Thus, we have shown that embryonic cardiospecific deletion alleles of one gene b-catenin results in delayed development and adult heart causes hypertrophy with age. Product Description popup.authors Бобик Василь Васильович Костецький Ігор Євгенович Мацевич Лариса Леонідівна Півень О.О. Сидорик Людмила Леонідівна popup.nrat_date 2020-04-02 Close