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Information × Registration Number 0212U008312, 0107U007151 , R & D reports Title Clinical and metabolic disturbances because Infection disease in children and methods its correction popup.stage_title Head Pipa Larisa Vladimirovna, Registration Date 14-12-2012 Organization Dovganeuk Inna popup.description2 Object of study - Acute enteric infection (AEI) without NDC and with NDC, meningitis (purulent meningitis - PM),purulent- septic diseases. Objective: To examine the role of oxidative modification products of plasma proteins, TNF-a, NSE as markers of toxicity depth, to optimize the pathogenetic therapy.Methods of study: Clinical: serological, immunological methods, biochemical instrumental and statistical ones.. Means of research: IEA (immune enzymatic analysis) apparatus with test systems, a set of monoclonal antibodies. The novelty of study: it was proved for the first time that in children with GM G(+) flora was discharged in 30.6% of cases, G (-), in 69.4%; clinical and morphological peculiarities of GM in children were identified depending on G (+) or G (-) of flora; we investigated the level of neuron-specific enolase under GM as a marker of the depth of destruction of nervous tissue, the interconnection between levels of OMP and severity of the disease; phenomenon of exsitotoxicity is a key mechanism of neuronal death in GM; clinical peculiarities of AEI were identified in children with EDC; it was found that the slow acetylation phenotype and association of erythrocyte antigens B (III) P (+) N is a marker of a risk of NDC development in children; atypical variant of gene TNF-a (308 A / G) is a predictor of generalized forms of pyo-septic conditions in children. Results: It will be developed and improved diagnostics of GM, sepsis and NDC using determination of identifying of NSE, genetic markers; neuroprotector citicoline and ibuprofen will be introduced for the integrated treatment of meningitis in children, for the treatment and prevention of NDC - trymetabol and syliks. Product Description popup.authors Грешило Михайло Сергійович Леньга Вікторія Романівна Мургіна Марина Миколаївна Пілюйко Наталя Василівна Свістільник Тетяна Володимирівна Філик Анатолій Володимирович popup.nrat_date 2020-04-02 Close