Registration Number
0212U008507,
0112U004814
, R & D reports
Title
Molecular mechanisms of antitumor activity of a new derivative side of maleimides.
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Head
Kharchuk Iryna,
Registration Date
11-01-2013
Organization
Taras Shevchenko Kiev university
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The level of inhibition of viability compound MI-1 epithelial cells is negligible for both proximal and distal tubules, but for the latter, according to the study of apoptosis, it is somewhat more pronounced. By mechanisms of cytotoxicity MI-1-induced apoptosis involved way of cell death. Daily effects of MI-1 for 20 weeks did not cause significant structural and functional changes in rat kidney. Expression of total and phosphorylated forms of ERK1 / 2 in the kidneys of rats subjected to the influence of MI-1 at a dose of 2.7 mg / kg increased especially in the proximal tubule. Increased expression of phosphorylated forms of ERK1 / 2 in renal tubules of mice under the influence of MI-1 indicates its potential toxicity in relation to the renal tubules, especially distal. However, increasing the content of total ERK1 / 2 in the proximal tubule under the influence of MI-1 may depend on de novo protein synthesis and promote the survival of proximal tubular epithelial cells under the effect of toxic factor or oxidative stress. Much more toxic compounds derived comparison dyhidropirolu D-1 indicates significant nephrotoxicity after its application.
Product Description
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Линчак О.В.
Рибальченко В.К.
Харчук І.В.
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2020-04-02
