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Information × Registration Number 0212U008690, 0112U006189 , R & D reports Title Production of biological active substances of microbial and synthetic origin for pharmaceutical preparations, wastes bioutilization and biotechnological industry popup.stage_title Head V. Novikov, Registration Date 26-12-2012 Organization Lviv Polytechnic National University popup.description2 The biosynthesis ofmicrobialsurfactantsby the bacteria of thegeneraRhodococcus, Pseudomonasand yeast of thegenusPhaffiawas studied: economiccarbonandnitrogensources fortheir production were selectedand the physico-chemicaland biologicalproperties of thebiosurfactants weredetermined. It was established thatthe microbial synthesissubstancescan be characterized aspromisingsurfactants bythe parametersof the surface tension, emulsifyingactivity andaspromising basesubstances forthe development of complexantimicrobialpreparations basedon thiosulfoacidestersandnaphthoquinonederivatives.Biosurfactant samples weresynthesizedfor production ofcomplexes withbiologicallyactive compoundswithnaphthoquinoneandthiosulfonatefragmentsto establishtheir impact ongrowth,permeabilityandhydrophobicityof membranes of anumber of bacteriaandfungi,antiviralandvirucidaleffectas well as theinfluence on the rateand depth ofanaerobicwaste utilization. Thiosulfonatederivativeswith naphthoquinonefragments were synthesized viasubstitutionreactionsof chlorine atomsinnaphthoquinonesystem.The optimumconditions forinteractionthiosulfoacidsaltsof2,3-dichloro-1,4-naphthoquinone were developed.Thiosulfonatederivativeswith 2-amino-1 ,4-naphthoquinonic fragments were synthesized. The interaction ofthiosulfoacidssaltswith 2-hydroxy-3-chloro-1,4-naphthoquinone and 6,7-dichloro-5,8-quinolinequinone was studied. The interaction ofS-ethyl ester of4-aminobenzenthiosulfoacidwith2,3-dichloro-1 ,4-naphthoquinone was investigated. The samples ofnew compounds were synthesized. Product Description popup.authors Карпенко О.В. Карпенко О.Я. Лубенець В.І. Новіков В.П. popup.nrat_date 2020-04-02 Close