Registration Number
0212U008690,
0112U006189
, R & D reports
Title
Production of biological active substances of microbial and synthetic origin for pharmaceutical preparations, wastes bioutilization and biotechnological industry
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Head
V. Novikov,
Registration Date
26-12-2012
Organization
Lviv Polytechnic National University
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The biosynthesis ofmicrobialsurfactantsby the bacteria of thegeneraRhodococcus, Pseudomonasand yeast of thegenusPhaffiawas studied: economiccarbonandnitrogensources fortheir production were selectedand the physico-chemicaland biologicalproperties of thebiosurfactants weredetermined. It was established thatthe microbial synthesissubstancescan be characterized aspromisingsurfactants bythe parametersof the surface tension, emulsifyingactivity andaspromising basesubstances forthe development of complexantimicrobialpreparations basedon thiosulfoacidestersandnaphthoquinonederivatives.Biosurfactant samples weresynthesizedfor production ofcomplexes withbiologicallyactive compoundswithnaphthoquinoneandthiosulfonatefragmentsto establishtheir impact ongrowth,permeabilityandhydrophobicityof membranes of anumber of bacteriaandfungi,antiviralandvirucidaleffectas well as theinfluence on the rateand depth ofanaerobicwaste utilization. Thiosulfonatederivativeswith naphthoquinonefragments were synthesized viasubstitutionreactionsof chlorine atomsinnaphthoquinonesystem.The optimumconditions forinteractionthiosulfoacidsaltsof2,3-dichloro-1,4-naphthoquinone were developed.Thiosulfonatederivativeswith 2-amino-1 ,4-naphthoquinonic fragments were synthesized. The interaction ofthiosulfoacidssaltswith 2-hydroxy-3-chloro-1,4-naphthoquinone and 6,7-dichloro-5,8-quinolinequinone was studied. The interaction ofS-ethyl ester of4-aminobenzenthiosulfoacidwith2,3-dichloro-1 ,4-naphthoquinone was investigated. The samples ofnew compounds were synthesized.
Product Description
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Карпенко О.В.
Карпенко О.Я.
Лубенець В.І.
Новіков В.П.
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2020-04-02
