Registration Number
0213U000121,
0111U010158
, R & D reports
Title
To work out the protocols of immune-correcting therapy for radiation therapy support in cancer patients with various types of vegetative regulation.
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Head
Sorochan P.P., Sukhina O.M.,
Registration Date
17-01-2013
Organization
Grigor'ev Institut for Medical Radiology
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Object of the research - development of chemotherapy complications and possibility of their correction depending on the type of vegetative regulation, amount of pro- and anti-inflammatory cytokines, changes in the level of cortisone, insulin, melatonin, blood and immunity parameters in patients with uterine body and breast cancer. Purpose of research - to individualize accompanying immune correcting therapy with consideration of the peculiarities of immune reactivity depending on the type of vegetative regulation. Methods of investigation and equipment - clinical, morphological, x-ray, hematological, immunological, biochemical, statistical; light and luminescent microscopes, spectrophotometer, blood and immunoenzyme analyzers. Theoretical and practical results - For the first time, it was determined that prevalence of sympathetic tone in patients with uterine body cancer is associated with development of anemia, reduction of the number of CD8+-Т-lymphocytes and daily production of melatonin, eosinophilia, monocytosis, hypercortisolemia, , increased level of cytokines. The patients with breast cancer with prevailing sympathetic tone demonstrated similar disorders except for eosinophilia. It was proven that all patients with prevailing parasympathetic tone had better indices of the quality of life. A method of accompanying immunotherapy was worked out based on the established regulations. Novelty - The peculiarities of immunological, hematological, and endocrine disorders associated with the type of vegetative regulation in cancer patients were established. Area of application - medicine, oncology, radiology.
Product Description
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Іваненко М.В.
Громакова І.А.
Громакова І.С.
Кононенко О.К.
Кругова І.М.
Кузьменко О.В.
Нікітін М.І.
Никифорова Н.А.
Пономарьов І.М.
Прохач Н.Е.
Слабодчиков М.Є.
Сорочан П.П.
Сухін В.С.
Сухіна О.М.
Шутов С.В.
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2020-04-02
