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Information × Registration Number 0213U002843, 0110U002607 , R & D reports Title To study the influence of introduction of stem cells on adaptation possibilities of the organism of adult and old mise under the action of damaging factors. popup.stage_title Head Bezrukov Vladislav Viktorovich, Butenko Gennadij Michajlovich, Registration Date 12-02-2013 Organization State Institution "Institute of Gerontology AMS Ukraine" popup.description2 It is shown that the introduction of the experimental animals doxorubicin and isoproterenol leads to myocardiopathy, accompanied by severe morphological changes in the myocardium and the activity of CPK in the blood serum. Developing heart failure is accompanied by a change in the behavioral reactions, which are determined by the elevated plus- maze test and the "open field" . Found that intoxication by doxorubicin and isoproterenol greatly reduces the potential for vascular dilatatorny in adult and old mice. The introduction of bone marrow stem cells has led to a certain normalization of biochemical and morphological parameters, as well as partial restoration of behavioral responses and contributed to a significant restoration of endothelium-dependent and endothelium -independent vasodilatory responses in adult animals. Product Description popup.authors Балла Ірина Анатоліївна Берук Ольга Олександрівна Кирик Віталій Михайлович Клименко Павло Павлович Лабунець Ірина Федорівна Олар Віталій Васильйович Парамонова Галина Іванівна Родниченко Анжела Євгенівна Сикало Ніна Володимирівна Холін Віктор Олександрович popup.nrat_date 2020-04-02 Close