Registration Number
0213U003170,
0109U000019
, R & D reports
Title
Clinical and immunological features of chronisation and unfavorable course of infectious diseases and correction methods
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Head
Zinchuk Olexander,
Registration Date
29-01-2013
Organization
Danylo Halytsky Lviv National Medical University
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The study of Lyme borreliosis, Viral hepatitis C, Leptospirosis, Toxoplasmosis and EBV-infection was conducted. Features of chronisation these infectious diseases were find. It is shown that the favorable course of acute Lyme borreliosis is largely due to the predominance of Th1 type immune response to a gradual transformation in the course of treatment in the Th2 type of immune response, as evidenced by decrease in the index IFN-gamma / IL-4 for 14 - day treatment. Genotype "ss" IL28 in Ukraine was found in 35% of patients with chronic hepatitis C. The most common form of IL28 gene polymorphisms in Ukraine is "ct" genotype - 52%. The vast majority (87%) patients with chronic hepatitis C, "ss" genotype IL28b achieved SVR by using PegIFN-RBV therapy. Cumulative assessment of predictors SVR (stage of fibrosis and genotype IL28) increases their positive predictive value to 92.3%. Certain immune cells specific reactivity with leukocyte cultures stimulated with toxoplasmosis antigen, is a highly effective method for specific diagnosis of toxoplasmosis, which also allows you to evaluate the effectiveness of a specific therapy. Designed based on multivariate models, multivariate index can accurately predict the severity of leptospirosis. High levels of NO2-along with a sharp decrease in the platelet count in the blood and encephalopathy were independent predictors of fatal leptospirosis. Unfavorable course (relapses and chronicity) EBV-infection was significantly more common in patients with severe disease in the acute period. A direct correlation between the severity of acute EBV-infection and the incidence of recurrence and chronicity in the future was find. Index IFN-gama/IL-4 at the first week of the disease was lower in patients who had relapses or chronicity compared with patients who have recovered and those of the control group.
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Адамович Олександр Петрович
Віслапуу Марія Леопольдівна
Ворожбит Ольга Богданівна
Герасун Борис Абрамович
Герасун Олександр Борисович
Грицко Роман Юліанович
Задорожний Андрій Михайлович
Зубач Олена Олександрівна
Кіселик Ігор Олексійович
Копитко Олександр Миколайович
Крижанська Марина Олександрівна
Покровська Тетяна Валеріївна
Річняк Тетяна Генрихівна
Телегін Дмитро Євгенович
Чорновіл Андрій Вячеславович
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2020-04-02
