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Information × Registration Number 0213U003307, 0110U000231 , R & D reports Title To reveal the pathogenic pathways of diabetes mellitus in Chernobyl NPP accident survivors exposed to ionizing radiation in dose range from 0.25 to 7.1 Gy popup.stage_title Head Kovalenko Oleksandr Mykolayovych, Registration Date 24-01-2013 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Object of research: survivors of the Chernobyl NPP accident, examined within KER program (liquidators of 1986 period, evacuees, residents of contaminated areas), aged 19 - 45 years at the time of the accident, total - 10,033 people. Of these, 309 people with diabetes were selected for in-depth clinical examination. Objective: at the background of study of the clinical and metabolic peculiarities of diabetes among persons exposed to radiation in the dose range of 0.25 to 7.1 Gy determine the mechanisms of their formation and develop the concept of the role of ionizing radiation in the development of disorders of carbohydrate metabolism. Methods - clinical, anthropometric, biochemical, hormonal, instrumental, statistical. Results and novelty. The high incidence of diabetes among liquidators of the Chernobyl NPP accident nearly 25 years after the event is 14.2% being 2.5 times higher vs. evacuees and residents of contaminated areas. The average absolute growth and the average growth rate of the frequency of diabetes among liquidators of the Chernobyl is 2.7 times greater than that of the population of Ukraine. In the dynamics of the 25-year observation of convalescents ARS and liquidators of the Chernobyl having no signs of medullar syndrome, the risk of diabetes since the time of exposure were determined with following factors (in order of importance) as age, hyperinsulinemia, BMI and cholesterol concentration in serum. Along with disorders of carbohydrate and lipid metabolism the changes of protein metabolism were found, particularly in ARS survivors. Signs of concentric hypertrophy of the left ventricular myocardium arise in them against the increased synthesis of collagen type I in extracellular matrix compared to the liquidators of the Chernobyl accident in 1986, in whom it was associated with inhibition of degradation processes. It is shown that structural changes in the pancreas of persons affected by the Chernobyl accident may indicate to a reduction of beta-cell functional completeness and thus indicate an insular insufficiency progression with development of type 2 diabetes. Among liquidators of the Chernobyl vs. residents of contaminated areas and people who are not exposed to radiation factor, a variant of diabetes characterized by reduced insulin secretion, conversion proinsulinu violation of insulin is often prevalent. Clinically this variant of the disease is characterized by the absence of obesity II-III degree, a significant increase in postprandial glycemia, presence of dyslipidemia, the need for insulin therapy in the form of mono-or combination therapy to achieve the diabetes compensation. Field of application - Radiation Medicine, Clinical Endocrinology. Degree of implementation - 26 scientific publications, presentations at scientific conferences at various levels - 8, patent for utility model - 1, patent application - 1, draft guidelines - 1. Product Description popup.authors Афанасьєв Дмитро Євгенович Ваколюк Катерина Олександрівна Верескун Сергій Борисович Камінський Олексій Валентинович popup.nrat_date 2020-04-02 Close