Registration Number
0213U004073,
0110U001177
, R & D reports
Title
To determine the influence of humoral inflamatory factors on the course and prognosis of the ischemic stroke
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Head
Mischenko T.S.,
Registration Date
31-01-2013
Organization
State Institution " Institute neurology, psychiatry and narcology NAMS of Ukraine"
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The subject of the investigation: 210 patients with ischemic stroke in acute, recovery, and consequent periods. 140 patients were followed up during 3 years after their strokes. The aim of the investigation: to study peculiarities of clinical-neurological impairments in patients after ischemic stroke and to define a role of humoral inflammatory factors in the pathogenesis and prognosis in order to improve measures for treatment and prevention. On the base of an integrated investigation performed it was demonstrated an important role of inflammation in the ischemic stroke pathogenesis and prognosis. The highest parameters of inflammation (hfCRP, fibrinogen, cytokines) are pointed out in the atherothrombotic subtype of stroke. It was revealed a direct correlation between levels of inflammatory markers and a stroke severity, and risk factors (hypercholesterolemia, diabetes mellitus, smoking, carotid stenosis). It was demonstrated that in the recovery period a decreasing of inflammatory marker levels occurred, which was less significant in atherothrombotic stroke. All of these reflect a level of a system inflammatory reaction and conditions of a prothrombotic threat. In was determined an influence of statins, antithrombotic medications (Disgren, Vessel-Due) on inflammatory markers and a vascular wall of internal carotid artery. It was defined a prognostic significance of inflammatory markers for risk of secondary vascular catastrophes and for a functional recovery.
Product Description
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Аборнєва Л.
Балкова Н.
Деревецька В.
Джандоєва Н.
Дмитрієва О.
Здесенко І.
Косова О.
Кутіков О.
Лінська Г.
Лапшина Л.
Лапшина Л.
Міщенко В.
Міщенко Т.
Перцева Т.
Песоцька О.
Петренко О.
Реміняк І.
Романова Л.
Слюсаренко І.
Харіна К.
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2020-04-02
