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Information × Registration Number 0213U004824, 0113U005215 , R & D reports Title Usage of redox-modulating compounds for enhancing of specificity of action of novel anticancer drugs popup.stage_title Head Stoika Rostyslav Stepanovych, Registration Date 27-12-2013 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 Combinatorial action of organic (selenomethionine) and inorganic selenium derivative (sodium selenite) together with modified form of vitamin B5 (D-panthetine) and conventional anticancer drugs doxorubicin and cisplatin was studied towards malignant human cells, characterized by different mechanisms of drug resistance. It was revealed that in low concentrations all studied antioxidants inhibit production of toxic superoxide anions by doxorubicin in human tumor cells.This process is also accompanied by an almost complete recovery of functional state of the target cells, which is manifested by disappearance of any signs of apoptosis and nuclear chromatin decondensation. Use of higher doses of sodium selenite and selenomethionine (1-5 uM), which are still physiologically non-toxic, however, led to increased death of tumor cells in combination with doxorubicin. At the same time studied antioxidants had no modulatory effects towards antitumor activity of another drug - cisplatin, which does not induce production of reactive oxygen species. Calculation of optimal concentrations of active selene derivative and D-panthetine in vivo will allow to develop improved chemotherapy regimens of cancer patients, which will allow to lower negative side effects of doxorubicin towards normal cells, and strengthen them towards malignant tumors. The results of thsi project are published in one scientific article and one thesis in the international conference proceedings. Product Description popup.authors Панчук Ростислав Русланович popup.nrat_date 2020-04-02 Close