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Registration Number

0213U005240, 0111U002051 , R & D reports

Title

To investigate some neoangiogenesis mechanisms by distal chronic disorders of lower limb arterial circulation by cell-tissue technology use.

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Head

Gryn Vladyslav Kostyantynovych,

Registration Date

29-03-2013

Organization

Public Institution "Gusak's Institute of Urgent and Recovery Surgery of Medical Sciences Academy of Ukraine"

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Experimental study was performed with the purpose to improve the efficiency of bone marrow multipotent mesenchymal stromal cells (MSC) application for chronic lower limb ischemia treatment and to find out more preferable method of cell transplantation. The purpose can be obtained only by neoangiogenesis process comparison in experimental models: animals with MSC transplantation and animals with aseptic inflammation by the autologous blood transplantation (other method of indirect revascularization). Functional parameters of animal limbs and laser Doppler flowmeter results were analyzed. Also histochemical and immunohistochemical studies were performed. Experimental results showed that intramuscular MSC transplantation is the best treatment method for function and blood circulation improvement, fibrous changes decrease and newformed vessels increase in rat's limbs with stimulated chronic lower limb ischemia.

Product Description

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Буше В. В.
Варшавер П. Л.
Гринь В. К.
Оберемко А. В.
Петрова М. В.
Попандопуло А. Г.
Постолюк І. Г.

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2020-04-02