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Information × Registration Number 0213U006010, 0108U002113 , R & D reports Title Objectification of the diagnostic and new approaches of treat-programs and rehabilitation of pathologic associated states at narcology diseases. popup.stage_title Head Sosin Ivan Kuzmich, Registration Date 04-04-2013 Organization The Kharkiv Post-graduate Medical Academy popup.description2 Background. The increasing prevalence of drug dependence (DD) is one of the most pressing issues of our time [4,8,9,30]. Even far from complete, official statistics strongly suggest that Ukraine unfolding epidemic and first opioid dependence (OD) [3,32,61]. Furthermore, due to essential objective reasons large part dependent on the drug people is ignored narcologists and therefore not counted in the official medical statistical reporting. This increases the relevance of indirect but objective markers (for example, the incidence of chronic hepatitis C (CHC) and other diseases transmitted by injection). Socio-demographic heterogeneity of the population of consumers significantly influences the duration of the latent period of development and prohrediyentnist opioid dependence [18,58,70]. These modern literature indicate unambiguous impact of comorbid disease in patients with opioid dependence, a high probability of occurrence of these somatic disorders that accompany the progress of health care and emergency complications that require immediate therapeutic intervention [10,12,15,28]. Lack of knowledge of modern forms of opioid dependence in this group of patients is reflected in the quality of care that is often without regard to the specific age, symptoms, and clinical course of the disease. Equally dangerous is postintoksykatsiyni psychopathology and somato correlates of opioid drug addiction, which are contraindications for active treatment. The therapeutic arsenal Clinical Addiction constantly updated with new methods of treatment, but the effectiveness of drug treatment remains inadequate. Therefore, the study of the diagnosis, clinical manifestations, treatment and prevention of opioid narcotics is one of the most important problems of modern medicine. The complexity and urgency of these problems dictate the urgent need to find, develop and implement innovative therapeutic complexes would possess sufficient compatibility with the drug-free and medicated therapies allowed to minimize the use of drugs to increase efficacy emergency narkopatolohiyi when you turn them into treatment and recovery programs. Expanding market psychopharmacological agents should rationally combined with synchronous approbation of potentiation able to express mode to solve the most complex and critical problems addiction [19,23,78, 82]. Development of adjuvant treatment and rehabilitation systems based on advanced medical technologies, the most promising of which presented method membrane plasmapheresis and laser therapy, is critical for all phases of intensive care substance abuse. However, the primary area of study and implementation of detoxification programs based on membrane plasmapheresis and laser methods have become urgent conditions in clinical opioid dependence, which largely determine the seriousness of the current drug situation in our country. The object of study - mental and behavioral disorders due to abnormal opioid dependence and comorbid with opiomaniyeyu states. Purpose of the study - epidemiological, socio-demographic, clinical, psychiatric, psychological, metabolic, immunological, morphological aspects of opioid dependence and comorbid diseases, predictors of its formation and markers to identify risk groups, as well as methods of diagnosis, prevention, combined treatment and prognosis of opioid dependence. Methods. Information-theoretical, epidemiological, socio-demographic, clinical, psychopathological, psychodiagnostic, laboratory (chemistry, immunoassay using chemiluminescence method of computer), instrumental (morphology), mathematical statistics. The purpose of the study. Based on complex integrated studies (clinical-epidemiological, socio-demographic, clinical - psychopathological, psychodiagnostic, laboratory, instrumental) develop new approaches to the treatment of emergency conditions in the clinic for opioid dependence, and its system of discrete modular medical and social prevention. The results of the research. For the first time in Ukrainian Addiction justified and suggests new therapeutic approaches that provide alternative and differentiated use in medical recovery and rehabilitation programs in drug addiction membrane plasmapheresis (MPF) and complex laser methods (LM). Designed and implemented modifications and tested modes MPF and LM, adapted to solve real problems and emergency planning Addiction. The efficiency of the impact of innovative block options MPF and LM, which includes selective modification for correction of certain clinical situations drug practices. Established scientifically sound methods rubryfikatsiya MPF and LM in clinical drug abuse. It is shown that in the complex treatment of emergency narkopatolohii opium genesis MPF and PE can be used as an alternative monometod and differentially combined with other drug-free and medicated methods. The dynamics of some pathophysiological indicators under the influence of MPF and LM indicates that the mechanism of their effect has sanogenetic pathogenic orientation. Proved normalizing effect of the proposed method on indicators of cerebral and peripheral hemodynamics, brain activity, homeostatic indicators. These data will serve as a theoretical basis for further study and expansion of the use of methods of MPF and LM in Psychiatry. Based on structural and functional analysis of the peculiarities of the internal interconnections performance history, laboratory and functional data modes MPF and LM, data status homeostatic substance abuse patients at different stages of treatment. Designed address combined methods of intensive comprehensive MPF and LM treatment of emergency conditions that allow the doctor to operate them effectively without any medical and technical constraints. Got a scientific justification appropriateness of MPF and LM in combination with infusion and extracorporeal therapies that potentiate the therapeutic effects of each other, which is extremely important for Supervision patients urgently profile with postintoksykatsiynym and hronioseptichnym syndrome. Introduced modifications electrochemical detoxification and hemokarboperfuziyi undertaken against simultaneous intravascular laser hematherapy that is resuscitation aspect Clinical Addiction. Research found that Election scope MPF and LM in drug practice is retsydyvonebezpechni situation postabstynentnoho and remisiynoho depressive period register, alhichnoho series dysomnichnyh disasters narkogennogo genesis. Of particular significance, this statement shall in patients with comorbid somato pathology, the presence of a stable factor in resistance to drug therapy, susceptibility to toxic-allergic and pyrogenic reactions, age peculiarities (adolescence and adolescence), where massive pharmacotherapy has significant limitations, or use it virtually impossible . These studies are basic in the scientific rationale and the creation of the study "ANTI Program Clinical Addiction" on the basis of innovative laser technologies. Revealed that a significant advantage of the developed complex MPF and LM methods for detoxification stage is the effect of blocking the biological mechanisms of transformation of drugs in severe deprivation syndrome. Clinical symptoms of withdrawal that while developing countries are more "velvety" current, relatively rudimentary symptoms are eliminated by repeated sessions MPF and LM therapy. Application of intensive MPF and LM therapy in rapid detoxification regimes can achieve the elimination of the clinic manifest forms of abstinence burdensome narkoasotsiyovanyh hastrytychnyh, hepatopatychnyh and vegetative symptoms. A concept suggests the presence of the MPF methods and LT adjuvant therapy properties, potentiated and in our terminology "sverhpotentsiyuvannya" therapeutic effects of antidepressant drugs, antykonvulsyvnoyi, neurometabolic and hepatoprotective action. This is extremely important when building therapeutic programs at the stage of correction emotional disorders, relief of cyclical behavioral paroxysms in the structure of actualization craving for psychoactive substances, recovery defitsitarnoy neuropsychiatric symptoms and hepatopatichnoyi clinic narkopatolohiyi. Publications. By research published books - 4 Guidelines - 3, Patent of Ukraine - 13 scientific papers - 140, novvedenn - 21. The structure and scope of research. Research presented in Ukrainian by 290 pages of typewritten text consists of an introduction, literature review, materials and methods of research, chapters own research, summarizing findings, conclusions, recommendations and practical applications. REFERENCES contains 119 items of domestic and foreign authors. Product Description popup.authors Волков Олександр Сергійович Гончарова Олена Юріївна Друзь Олег Васильович Мисько Галина Миколайовна Овчаренко Микола Олексійович Сквира Іван Михайлович Слабунов Олег Степанович Сосін Іван Кузьмич Чайка Сергій Васильович Чуєв Юрій Федорович popup.nrat_date 2020-04-02 Close