Registration Number
0213U006377,
0113U005130
, R & D reports
Title
Determination of degree of malignant histogenesis using domestic monoclonal antibodies
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Head
Sidorenko Svetlana Pavlivna,
Registration Date
15-05-2013
Organization
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology
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The research technology of murine monoclonal antibody IPO-38 production, technological laboratory regulations of IPO-38 antigen expression detection in isolated cells and tissue samples were developed. Studies of IPO-38 antigen expression levels in malignant tumors of different histogenesis, namely, lymphoid and myeloid forms of leukemia, non-Hodgkin's malignant lymphomas and tumors of the central nervous system were performed. A significant heterogeneity by expression of IPO-38 antigen was revealed in different cytological and histological variants of malignant tumors. It was shown that high levels of IPO-38 antigen expression correlate with poor prognosis in small lymphocytes lymphomas and glial tumors of different grade. Thus, the identification of IPO-38 antigen using national monoclonal antibodies can be used to assess the degree of tumor malignancy.
Product Description
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Глушко Наталія Віталіївна
Гордієнко Інна Михайлівна
Дасюкевич Ольга Йосипівна
Завелевич Михайло Петрович
Ковалевська Лариса Миколаївна
Ніцак Оксана Вікторівна
Погрібний Петро Васильович
Прокопенко Ігор Вікторович
Сидоренко Світлана Павлівна
Шишко Євгенія Денисівна
Шлапацька Лариса Миколаївна
Юрченко Марія Юріївна
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2020-04-02
